130797-57-8

Upstream product

• 151598-88-8 ethyl 2-ethoxy-2-methylpropanoate 
• 15001-71-5 2-ethoxy-2-methyl-propanoic acid 
• 22665-69-6 2-ethoxy-2-methylpropan-1-ol 
• 98561-16-1 2-bromo-1,1-diethoxy-2-methyl-propane 

Downstream Products

• 1575819-81-6 tert-butyl (2-(4-chlorobenzamido)-1-((1-(2-cyano-4-ethoxy-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate 
• 1575817-60-5 4-chloro-N-(1-((1-(2-cyano-4-ethoxy-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-1H-benzo[d]imidazol-2-yl)benzamide 
• 1414357-74-6 2-((R)-2-((4-amino-3-(4-(2,3-difluorophenoxy)-2-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-4-ethoxy-4-methylpent-2-enenitrile 2,2,2-trifluoroacetate 
• 1414356-04-9 N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methylethyl]-2-cyano-4-ethoxy-4-methylpent-2-enamide 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AS RLK and ITK INHIBITORS

The present disclosure is directed to certain inhibitors of RLK and ITK of formula (I), pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by inhibition of RLK and ITK.

BENZIMIDAZOLE DERIVATIVES AS ITK INHIBITORS

The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular ITK, pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by such kinases.

2-THIOXANTHINE DERIVATIVES ACTING AS MPO-INHIBITORS

The present invention relates to a compound according to Formula (I) wherein R1 is selected from C1-C6 alkyl, and said C1-C6 alkyl is substituted with C1-C6 alkoxy; and at least one of said C1-C6 alkyl or said C1-C6 alkoxy is branched; or a pharmaceutically acceptable salt thereof, solvate or solvate of a salt thereof, to compositions containing the compound and the use thereof in therapy.

NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY

There are disclosed novel compounds of formula (I) wherein R1, R12, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing