1308279-75-5Relevant academic research and scientific papers
THERAPEUTIC COMPOUNDS
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Page/Page column 35, (2011/07/09)
The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for prepa
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4- hydroxyphenyl]-3-chlorocinnamic acid
Xia, Zebin,Farhana, Lulu,Correa, Ricardo G.,Das, Jayanta K.,Castro, David J.,Yu, Jinghua,Oshima, Robert G.,Reed, John C.,Fontana, Joseph A.,Dawson, Marcia I.
experimental part, p. 3793 - 3816 (2011/08/06)
(E)-4-[3'-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell cycle arrest and apoptosis of cancer cells. Because its pharmacologic properties-solubility, bioavailability, and toxicity-required improvement for translation, s
