1308320-05-9

Basic information

• Product Name: methyl 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoate
• Synonyms: methyl 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoate
• CAS NO: 1308320-05-9
• Molecular Weight: 479.279
• Mol File: 1308320-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoate(1308320-05-9)
• EPA Substance Registry System: methyl 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoate(1308320-05-9)

Safety Data

• Hazardous Substances Data: 1308320-05-9(Hazardous Substances Data)

Upstream product

• 1308319-78-9 methyl 3-(2-chloro-6-nitroquinazolin-4-ylamino)propanoate 
• 1308319-97-2 methyl 3-(2-amino-6-nitroquinazolin-4ylamino)propanoate 
• 102-36-3 3,4-dichlorophenylisocyanate 
• 74173-77-6 2,4-dichloro-6-nitro-quinazoline 
• 32618-85-2 6-Nitro-1H-quinazoline-2,4-dione 
• 616-79-5 2-amino-5-nitro-benzoic acid 

Downstream Products

• 1308319-74-5 3-(2-(3-(3,4-dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors

A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC50 value at the level of 10-6 mol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The design and optimization of novel small molecule Pin1 inhibitors will be guided by the results of this report.