13084-31-6

Basic information

• Product Name: 2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole
• Synonyms: 2-(4-Methylphenyl)-4,5-dihydro-1,3-thiazole; thiazole, 4,5-dihydro-2-(4-methylphenyl)-
• CAS NO: 13084-31-6
• Molecular Formula: C₁₀H₁₁NS
• Molecular Weight: 177.266
• Mol File: 13084-31-6.mol

Chemical Properties

• Boiling Point: 293.3°C at 760 mmHg
• Flash Point: 131.2°C
• Density: 1.14g/cm³
• Vapor Pressure: 0.00304mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole(13084-31-6)
• EPA Substance Registry System: 2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole(13084-31-6)

Safety Data

• Hazardous Substances Data: 13084-31-6(Hazardous Substances Data)

Usage

1,3-thiazole derivative

A chemical compound that is based on a 1,3-thiazole ring system.

Heterocyclic compound

Contains a five-membered ring with sulfur and nitrogen atoms.

4-methylphenyl group

A methyl group (a carbon atom bonded to three hydrogen atoms) attached to a phenyl group (a six-membered carbon ring with delocalized electrons) attached to the 2-position of the thiazole ring.

Potential applications

Has potential uses in the pharmaceutical and agrochemical industries.

Biological activities

Known to have various biological activities such as antimicrobial, antitumor, and anti-inflammatory properties.

Synthesis and properties

Its synthesis and properties make it a valuable compound for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 349136-95-4 4-methyl-benzoic acid-(2-bromo-ethylamide) 
• 13084-24-7 1-(4-methyl-thiobenzoyl)-aziridine 
• 2362-62-1 4-methylthiobenzamide 
• 141-43-5 ethanolamine 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 104-85-8 para-methylbenzonitrile 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 874-60-2 4-methyl-benzoyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 99-94-5 p-Toluic acid 
• 60-23-1 Cysteamine 
• 7391-28-8 p-tolueneacetonitrile 
• 153783-99-4 (Oxo-p-tolyl-ethanesulfonyl)-acetic acid methyl ester 

Downstream Products

• 96160-01-9 3-Methyl-2-p-tolyl-4,5-dihydro-thiazol-3-ium; iodide 
• 27088-83-1 2-(4-Methylphenyl)thiazole 

Relevant articles and documents

A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids

N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.

Selective thioacylation of amines in water: A convenient preparation of secondary thioamides and thiazolines

Primary thioamides have been utilised directly in water, without any derivatisation, to selectively thioacylate primary amines. By employing 2-hydroxyethylamines, the reaction can be extended to the preparation of 2-thiazolines via formation of β-hydroxythioamides.

A straightforward metal-free synthesis of 2-substituted thiazolines in air

A base-catalysed procedure for the synthesis of 2-substituted thiazolines from nitriles and cysteamine hydrochloride under solvent-free conditions is presented. This straightforward approach allows high conversion for a broad range of nitriles and an easy

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

One-pot synthesis of 2-arylthiazolines with 1-butyl-3-methylimidazolium tribromide as a catalytic reagent

A simple, inexpensive, and efficient one-pot synthesis of 2-arylthiazoline derivatives under solvent-free conditions using a catalytic amount of 1-butyl-3-methylimidazolium tribromide with excellent product yields is reported. This methodology provides ea

Tribromomelamine: A novel and efficient catalyst for the synthesis 2-arylthiazolines under solvent-free conditions

A novel procedure for the synthesis of 2-arylthiazolines through one-pot condensation of of nitriles with 2-aminoethanethiol in the presence of tribromomelamine as catalyst under solvent-free conditions is described.

Solvent-free tandem synthesis of 2-thiazolines and 2-oxazolines catalyzed by a copper catalyst

Tandem reactions of nitriles with 2-aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (Cu II2L4, L = methacrylate) were employed to prepare 2-thiazolines and 2-ox

Easy access to thiazolines and thiazines via tandem S-alkylation- cyclodeamination of thioamides/haloamines

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.