130855-57-1

Usage

Uses

Used in Pharmaceutical Industry:
ALPHA-METHYL-L-4-FLUOROPHE is used as a key intermediate in the synthesis of zwitterionic CCR3 antagonists, such as AZ12436092. This application is significant because it aids in the discovery and development of new drugs that can potentially treat various medical conditions by targeting specific receptors.
Chemical Properties:
ALPHA-METHYL-L-4-FLUOROPHE is characterized by its white powder form, which is a common physical state for many chemical compounds used in the pharmaceutical industry. Its chemical properties make it a valuable component in the synthesis of various drugs and therapeutic agents.

Upstream product

• 126402-81-1 isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-46-1 4-Fluorobenzyl bromide 
• 56-41-7 L-alanin 

Downstream Products

• 1056901-30-4 3-(S)-(4-fluoro-phenyl)-2-methyl-2-pyrrol-1-yl-propionic acid 
• 1056901-19-9 N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide 
• 1056901-32-6 5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A new approach to the efficient method for the asymmetric synthesis of (S)-O-, M-, P-fluorophenylalanines and their 2-methyl-substituted analogs

The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-[(N0-2-chlorobenzylprolyl)- amino]benzophenone and (S)-2-N-[N′-(3, 4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed.

Chiral salen-metal complexes as novel catalysts for asymmetric phase transfer alkylations

Chiral, salen-metal complexes have been tested as catalysts for the C- alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1-10% of the catalyst

Asymmetric synthesis of organoelement analogues of natural products; Part 12: General method for the asymmetric synthesis of fluorine-containing phenylalanines and α-methyl(phenyl)alanines via alkylation of the chiral nickel(II) Schiff's base complexes of

Nickel(II) complexes of Schiff's bases derived from (S)-o-[(N-benzyl]prolyl)amino]benzophenone [N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide] (BBP) and glycine or alanine have been used for asymmetric synthesis of fluoro (S)-phenylalanines and (S

ASYMMETRIC SYNTHESIS OF HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. 2. A CONVENIENT PREPARATIVE METHOD FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE (S)-(-)-o-, m-, and p-FLUOROPHENYLALANINES AND THEIR 2-METHYL-SUBSTITUTED ANALOGS.

A convenient preparative method for the synthesis of the enantiomerically pure o-, m-, and p-fluorophenylalanines and their α-methyl-substituted analogs by means of the alkylation with the corresponding fluorine-containing benzyl chlorides of glycine and

RESOLUTION OF α-METHYL AMINO ESTERS BY CHYMOTRYPSIN

The resolution of DL-α-MeTrp-OMe HCl, DL-α-MePhe-OMe HCl and DL-α-Me-pF-Phe-OMe HCl have been achieved using α-chymotrypsin at pH 5.0.