130855-57-1

Basic information

• Product Name: ALPHA-METHYL-L-4-FLUOROPHE
• Synonyms: ALPHA-METHYL-L-4-FLUOROPHE;ALPHA-METHYL-L-4-FLUOROPHENYLALANINE;a-Methyl-L-4-Fluorophenylalanine;(S)-2-AMino-3-(4-fluorophenyl)-2-Methylpropanoic acid;α-Me-Phe(4-F)-OH;(S)-α-Methyl-4-fluorophenylalaine;α-Methyl-L-4-Fluorophenylalanine≥ 98% (HPLC);Alpha-Methyl-Phe(4-F)-OH
• CAS NO: 130855-57-1
• Molecular Formula: C₁₀H₁₂FNO₂
• Molecular Weight: 197.21
• Product Categories: Unusual amino acids;α-Methyl Amino Acids
• Mol File: 130855-57-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ALPHA-METHYL-L-4-FLUOROPHE(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-METHYL-L-4-FLUOROPHE(130855-57-1)
• EPA Substance Registry System: ALPHA-METHYL-L-4-FLUOROPHE(130855-57-1)

Safety Data

• Hazardous Substances Data: 130855-57-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

4-Fluoro-α-methyl-L-phenylalanine is used in the discovery of series of zwitterionic CCR3 antagonists, AZ12436092.

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 56-41-7 L-alanin 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 126402-81-1 isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate 

Downstream Products

• 1056901-19-9 N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide 
• 1056901-32-6 5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid ethyl ester 
• 1056901-30-4 3-(S)-(4-fluoro-phenyl)-2-methyl-2-pyrrol-1-yl-propionic acid 

Relevant articles and documents

A new approach to the efficient method for the asymmetric synthesis of (S)-O-, M-, P-fluorophenylalanines and their 2-methyl-substituted analogs

The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-[(N0-2-chlorobenzylprolyl)- amino]benzophenone and (S)-2-N-[N′-(3, 4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed.

Chiral salen-metal complexes as novel catalysts for asymmetric phase transfer alkylations

Chiral, salen-metal complexes have been tested as catalysts for the C- alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1-10% of the catalyst

ASYMMETRIC SYNTHESIS OF HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. 2. A CONVENIENT PREPARATIVE METHOD FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE (S)-(-)-o-, m-, and p-FLUOROPHENYLALANINES AND THEIR 2-METHYL-SUBSTITUTED ANALOGS.

A convenient preparative method for the synthesis of the enantiomerically pure o-, m-, and p-fluorophenylalanines and their α-methyl-substituted analogs by means of the alkylation with the corresponding fluorine-containing benzyl chlorides of glycine and