130860-33-2

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 101-39-3 2-methyl-3-phenyl-2-propenal 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 130860-34-3 (E)-α-methylcinnamaldehyde tosylhydrazone 
• 956360-13-7 2-(3-chlorophenyl)-5-[(E)-1-methyl-2-phenylvinyl]-2H-tetrazole 
• 13808-62-3 4-methyl-3-phenyl-1H-pyrazole 
• 1385069-00-0 1-allyl-4-methyl-3-phenyl-1H-pyrazole 
• 1385068-97-2 (4-methyl-3-phenyl-1H-pyrazol-1-yl)(phenyl)methanone 
• 1385068-94-9 1-benzyl-4-methyl-3-phenyl-1H-pyrazole 
• 130860-35-4 ((E)-2-Methyl-hept-2-enyl)-benzene 
• 130860-36-5 ((Z)-2-Methyl-hept-2-enyl)-benzene 

Relevant academic research and scientific papers

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.

MGLUR5 MODULATORS

The present invention is directed to compounds of formula (I) Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in

TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS

The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.