1308652-73-4Relevant academic research and scientific papers
Facile synthetic entry into rotationally restricted 9-arylacridines
Zhang, Jianguo,Saczewski, Jaroslaw,Wolinska, Ewa,Strekowski, Lucjan
, p. 245 - 247 (2013)
The treatment of 2-(trifluoromethyl)aniline with 2,6- dimethylphenylmagnesium bromide yields 1-methyl-9-(2,6-dimethylphenyl)acridine by the formal reaction of one equivalent of the aniline and two equivalents of the Grignard reagent. Interestingly, one of the methyl groups is eliminated during the reaction, and the product contains three methyl groups only. In a similar way, the reaction of 2-(trifluoromethyl)aniline with 2-ethylphenylmagnesium bromide furnishes 9-(2-ethylphenyl)acridine devoid of one ethyl group. The mechanism is discussed.
Highly efficient carbazolyl-derived phosphine ligands: Application to sterically hindered biaryl couplings
Chun To, Sheung,Yee Kwong, Fuk
supporting information; experimental part, p. 5079 - 5081 (2011/06/10)
A new family of phosphine ligands bearing a bulky carbazolyl scaffold is described. With the combination of ligand 2a and Pd(OAc)2, difficult tri-ortho-substituted biaryl couplings are accomplished smoothly. In particular, the catalyst loading as low as 0.02 mol% of Pd for non-activated 2,6-disubstituted aryl chloride coupling can be achieved.
