120796-24-9

Usage

InChI:InChI=1/C18H9N2O4/c1-7-5-9-12(11(22)6-7)14-15(16(9)20-19)18(24)13-8(17(14)23)3-2-4-10(13)21/h2-6H,1H3,(H,21,24)/q-1/p+1

Upstream product

• 107941-22-0 2-bromo-1,4,5-trimethoxynaphthalene 
• 1308657-81-9 4-hydroxy-5,9,10-trimethoxy-2-methyl-11H-benzo[b]fluoren-11-one 
• 1308657-84-2 3-(methoxymethoxy)-5-methyl-2-(1,4,5-trimethoxynaphthalen-2-yl)benzoic acid 
• 1308657-82-0 3-(methoxymethoxy)-5-methyl-2-(1,4,5-trimethoxynaphthalen-2-yl)benzaldehyde 
• 180912-27-0 4,5,9,10-tetrahydroxy-2-methyl-benzo[b]fluoren-11-one 
• 180912-25-8 5,10-dihydroxy-4,9-dimethoxy-2-methyl-benzo[b]fluoren-11-one 

Downstream Products

• 870465-37-5 acetic acid 9-acetoxy-5-hydroxy-2-methyl-10-oxo-11-phenyl-10H-benzo[b]fluoren-4-yl ester 
• 870465-34-2 4,5,9-trihydroxy-2-methyl-11-phenyl-benzo[b]fluoren-10-one 

Relevant academic research and scientific papers

Syntheses of prekinamycin and a tetracyclic quinone from common synthetic intermediates

Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel-Crafts reaction of 2-(naphthalen-2-yl)benzoic acid, and diazotization in ten steps from 3,5-dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and the tetracyclic quinone core for kinamycins was synthesized. Palladium-catalyzed site-selective hydroxylation of a benzoic acid derivative with the AB-D ring part was successfully applied to the selective D-ring functionalizations. Copyright