1308657-93-3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 745809-48-7 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde 
• 1315504-12-1 C₃₅H₃₁NO₉ 
• 1315504-11-0 C₄₁H₄₅NO₉Si 
• 1315504-10-9 C₄₄H₄₇F₃O₉Si 
• 1315504-09-6 C₄₄H₄₇F₃O₉Si 
• 1315503-85-5 C₃₄H₄₀O₇Si 
• 1315503-84-4 C₃₄H₄₀O₇Si 
• 1315503-83-3 1-(3-(tert-butyldimethylsilyloxy)-5-methylphenyl)but-3-en-2-one 
• 1315504-08-5 2-(3-(tert-butyldimethylsilyloxy)-5-methylphenyl)-N-methoxy-N-methylacetamide 
• 367261-75-4 2-(3-hydroxy-5-methylphenyl)acetic acid 
• 1261828-74-3 2-(3-(tert-butyldimethylsilyloxy)-5-methylphenyl)acetonitrile 

Relevant academic research and scientific papers

Syntheses of prekinamycin and a tetracyclic quinone from common synthetic intermediates

Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel-Crafts reaction of 2-(naphthalen-2-yl)benzoic acid, and diazotization in ten steps from 3,5-dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and the tetracyclic quinone core for kinamycins was synthesized. Palladium-catalyzed site-selective hydroxylation of a benzoic acid derivative with the AB-D ring part was successfully applied to the selective D-ring functionalizations. Copyright

Total synthesis of landomycin A, a potent antitumor angucycline antibiotic

The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps.