745809-48-7

Basic information

• Product Name: 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde
• Synonyms: 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde
• CAS NO: 745809-48-7
• Molecular Weight: 250.413
• Mol File: 745809-48-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde(745809-48-7)
• EPA Substance Registry System: 3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde(745809-48-7)

Safety Data

• Hazardous Substances Data: 745809-48-7(Hazardous Substances Data)

Upstream product

• 136386-75-9 (3-bromo-5-methyl-phenoxy)-tert-butyl-dimethyl-silane 
• 68-12-2 N,N-dimethyl-formamide 
• 108-39-4 3-methyl-phenol 
• 108-68-9 3,5-Dimethylphenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1308657-93-3 1-(bromomethyl)-3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzene 
• 58169-99-6 2,3,4,6-tetrabromo-5-methyl-phenol 
• 34946-83-3 2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone 

Downstream Products

• 745809-49-8 1-[3-(tert-butyldimethylsilanyloxy)-5-methylphenyl]but-3-yn-1-ol 
• 1308657-94-4 2-bromo-3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzaldehyde 
• 745809-51-2 acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester 
• 745809-58-9 2-[2-(tert-butyldimethylsilanyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone 
• 745809-52-3 2-[2-(tert-butyldimethylsilanyloxy)-2-(3-hydroxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone 
• 745809-57-8 1-(tert-butyldimethylsilanyloxy)-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene 
• 745809-50-1 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene 

Relevant articles and documents

Syntheses of prekinamycin and a tetracyclic quinone from common synthetic intermediates

Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel-Crafts reaction of 2-(naphthalen-2-yl)benzoic acid, and diazotization in ten steps from 3,5-dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and the tetracyclic quinone core for kinamycins was synthesized. Palladium-catalyzed site-selective hydroxylation of a benzoic acid derivative with the AB-D ring part was successfully applied to the selective D-ring functionalizations. Copyright