130867-91-3Relevant academic research and scientific papers
Synthesis of some 1-(dihydroxypropyl)pyrazolo-pyrimidines and in vivo evaluation of their antileishmanial and antitrypanosomal activity
Gatta, F.,Perotti, F.,Gradoni, L.,Gramiccia, M.,Orsini, S.,et al.
, p. 419 - 424 (2007/10/02)
A number of 1-(2,3-dihydroxypropyl)- and 1-pyrazolopyrimidines were synthesized.Some of these compounds were evaluated for their activity against Leishmania infantum and Trypanosoma brucei brucei in mice.The highest degree of antileishmanial activity was displayed by the 4-amino-1-(RS)-(2,3-dihydroxypropylpyrazolopyrimidine 11a, which yielded a 87percent and 96percent parasite inhibition in a standard 5-day test and in a long-term (14 days) treatment, respectively, though full cures of animals were not achieved.On the contrary, thisderivative did not significantly prolong the survival of T b brucei infected mice.
