85608-73-7Relevant academic research and scientific papers
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides
Derudas, Marco,Vanpouille, Christophe,Carta, Davide,Zicari, Sonia,Andrei, Graciela,Snoeck, Robert,Brancale, Andrea,Margolis, Leonid,Balzarini, Jan,McGuigan, Christopher
supporting information, p. 7876 - 7896 (2017/10/06)
Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) phosphate prodrugs, we herein report the ProTide approach applied to a series of acyclic nucleosides aimed at the identification of novel and selective antiv
Synthesis and biological properties of water-soluble p- boronophenylalanine derivatives. Relationship between water solubility, cytotoxicity, and cellular uptake
Nemoto,Cai,Asao,Iwamoto,Yamamoto
, p. 1673 - 1678 (2007/10/02)
Water-soluble p-boronophenylalanine (BPA) derivatives having cascade polyols, the monohydroxy derivative BPA(OH) (4), the dihydroxy analogue BPA(OH)2 (5), and the tetrahydroxy analogue BPA(OH)4 (6), were synthesized in order to eluci
A New Water-soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy
Nemoto, Hisao,Iwamoto, Satoshi,Nakamura, Hiroyuki,Yamamoto, Yoshinori
, p. 465 - 468 (2007/10/02)
A p-boronophenylalanine (BPA) derivative, that is ca. thousand times more water-soluble and is incorporated with higher tumour/normal cell ratio than BPA itself, has been synthesized.
Synthesis and antiherpes simplex virus activity of 9-[(1,3-dihydroxy-2-propylthio)methyl]guanine
McGee,Martin,Smee,Matthews,Verheyden
, p. 1242 - 1245 (2007/10/02)
The synthesis of the thio analogue (thio-DHPG, 2) of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG) is described. The synthesis of 2 proceeded via the condensation of acetoxymethyl sulfide with diacetylguanine to give the protected nucleoside analogue
