1308718-72-0

Upstream product

• 66176-39-4 4-(bromomethyl)benzene-1-sulfonyl chloride 
• 78-81-9 isobutylamine 

Downstream Products

• 1308719-05-2 4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)-N-(isobutyl)benzenesulfonamide 
• 1613303-91-5 4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide 
• 1613304-95-2 N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)benzenesulfonamide 
• 1613303-90-4 N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide 

Relevant academic research and scientific papers

BENZENE SULFONAMIDE DERIVATIVES AND THEIR USE AS RORC MODULATORS

Compounds of the formula la or lb: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, D, E, G, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS

Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Design, synthesis, and invitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

As part of our studies focused on the design of 1-[((hetero)aryl- and piperidinylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, we report the development of new extended benzylamine derivatives substituted at the para p