1308755-72-7Relevant academic research and scientific papers
ZrCl4-mediated regio- and chemoselective friedel-crafts acylation of indole
Guchhait, Sankar K.,Kashyap, Maneesh,Kamble, Harshad
, p. 4753 - 4758 (2011)
An efficient method for regio- and chemoselective Friedel-Crafts acylation of indole using acyl chlorides in the presence of ZrCl4 has been discovered. It minimizes/eliminates common competing reactions that occur due to high and multiatom-nucleophilic character of indole. In this method, a wide range of aroyl, heteroaroyl alkenoyl, and alkanoyl chlorides undergo smooth acylation with various indoles without NH protection and afford 3-acylindoles in good to high yields.
