1308889-25-9

Upstream product

• 1308888-98-3 3-(((benzyloxy)carbonyl)amino)-6-methoxy-8-methyl-2-oxo-2H-chromen-7-yl acetate 
• 1160952-37-3 N-(7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide 
• 224779-27-5 tert-butyl 3-hydroxy-1,2,3,6-tetrahydropyridine-N-carboxylate 
• 1308889-58-8 C₁₃H₁₃NO₅ 
• 1160952-38-4 3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-6-methoxy-8-methyl-2-oxo-2H-chromen-7-yl acetate 
• 1083313-80-7 3',6-dimethoxy-[1,1'-biphenyl]-3-carbonyl chloride 
• 1083313-05-6 3′,6-dimethoxy-[1,1′-biphenyl]-3-carboxylic acid 
• 1083312-78-0 benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate 

Downstream Products

• 1160950-95-7 3',6-dimethoxy-N-(6-methoxy-8-methyl-2-oxo-7-(1,2,3,6-tetrahydropyridin-3-yloxy)-2H-chromen-3-yl)biphenyl-3-carboxamide 
• 1160950-97-9 C₃₃H₃₂N₂O₈ 
• 1160950-96-8 3',6-dimethoxy-N-(6-methoxy-8-methyl-7-(1-methyl-1,2,3,6-tetrahydropyridin-3-yloxy)-2-oxo-2H-chromen-3-yl)biphenyl-3-carboxamide 
• 1160951-25-6 C₃₃H₃₄N₂O₈ 

Relevant academic research and scientific papers

Engineering an antibiotic to fight cancer: Optimization of the novobiocin scaffold to produce anti-proliferative agents

Development of the DNA gyrase inhibitor, novobiocin, into a selective Hsp90 inhibitor was accomplished through structural modifications to the amide side chain, coumarin ring, and sugar moiety. These species exhibit ?700- fold improved anti-proliferative activity versus the natural product as evaluated by cellular efficacies against breast, colon, prostate, lung, and other cancer cell lines. Utilization of structure- activity relationships established for three novobiocin synthons produced optimized scaffolds, which manifest midnanomolar activity against a panel of cancer cell lines and serve as lead compounds that manifest their activities through Hsp90 inhibition.