130898-24-7Relevant academic research and scientific papers
Bond rotation dynamics of N-cycloalkenyl-N-benzyl α-haloacetamide derivatives
Guthrie, David B.,Damodaran, Krishnan,Curran, Dennis P.,Wilson, Paul,Clark, Andrew J.
supporting information; experimental part, p. 4262 - 4266 (2009/09/08)
(Chemical Equation Presented) Barriers to rotation of the N-alkenyl bond in a series of N-cycloalkenyl-N-benzyl α-haloacetamide derivatives have been measured by variable-temperature NMR experiments. The barriers range from 10 to 18 kcal/mol, depending on ring size and on substituents on the cycloalkene and the amide. The observed trends aid in the design of substituent combinations that provide resolvable enantiomers or diastereomers at ambient temperature. The compounds undergo 4-exo and 5-endo radical cyclizations at rates that may be faster or slower than the estimated rate of N-alkenyl bond rotation in the derived radicals, depending on the substituents.
Enamine Chemistry. Part 36. Alkylation of Imines of Medium-Large Ring Ketones with Electrophilic Alkenes
Hickmott, Peter W.,Jutle, Kasturi K.,Pienar, Daniel H.
, p. 2399 - 2402 (2007/10/02)
The alkylation of the benzylamine imines of cycloheptanone, cyclo-octanone, and cyclododecanone with acrylonitrile, methyl acrylate, methyl vinyl sulphone, phenyl vinyl ketone, and phenyl vinyl sulphone, has been studied.The course of the reaction is surp
