130907-16-3

Upstream product

• 176910-67-1 2-(4-methoxyphenylethynyl)benzaldehyde 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 1185882-07-8 C₁₆H₁₈O₂ 
• 93651-99-1 2-<2-(4-Methoxy-phenyl)-ethyl>-benzoesaeure-methylester 
• 130818-20-1 2-(2-(4-methoxyphenyl)ethynyl)benzoic acid methyl ester 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 14525-71-4 2-<3-(4-methoxyphenyl)ethyl>benzoic acid 
• 102459-44-9 4'-methoxy-bibenzyl-2-carboxylic acid anilide 

Downstream Products

• 1185881-52-0 5-(2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1185881-61-1 3'-(4-methoxyphenyl)-2,2-dimethyl-3',4'-dihydro-1'H-spiro[[1,3]dioxane-5,2'-naphthalene]-4,6-dione 
• 1185881-68-8 dimethyl 3-(4-methoxyphenyl)-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate 
• 1185881-57-5 dimethyl 2-(2-(4-methoxyphenethyl)benzylidene)malonate 
• 1361132-05-9 5-(2-(4-methoxyphenethyl)benzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione 
• 1361132-14-0 3-(4-methoxyphenyl)-1',3'-dimethyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione 
• 1182624-46-9 3-(4-methoxyphenyl)-2-(4-methylbenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 1363394-64-2 N-(2-(4-methoxyphenethyl)benzylidene)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Concise route to 3-arylisoquinoline skeleton by lewis acid catalyzed c(sp3)-h bond functionalization and its application to formal synthesis of (±)-Tetrahydropalmatine

An expeditious route to furnish an isoquinoline skeleton via hydride shift mediated C-H bond functionalization was developed. In this process, an unusual [1,5]-H shift without the assistance of the adjacent heteroatom took place to produce tetrahydroisoquinoline derivatives in good to excellent chemical yields. The formal synthesis of (±)-tetrahydropalmatine was achieved by exploiting this new transformation.

Rapid access to 3-aryltetralin skeleton via C(sp3)-H bond functionalization: Investigation on the substituent effect of aromatic ring adjacent to C-H bond in hydride shift/cyclization sequence

The concise construction of 3-aryltetralin skeleton via hydride shift mediated C-H bond functionalization was achieved. In this process, the benzylic [1,5]-H shift occurred smoothly to furnish tetralin derivatives in good to excellent chemical yields. The electronic and steric properties of the aromatic ring adjacent to the C-H bond influenced significantly the reactivity of this transformation.

Functionalization of Csp3-H bond-Sc(OTf)3-catalyzed domino 1,5-hydride shift/cyclization/Friedel-Crafts acylation reaction of benzylidene Meldrum's acids

Under Sc(OTf)3 catalysis, benzylidene Meldrum's acids bearing a tethered p-methoxyphenethyl group were observed to undergo a [1,5]-hydride shift/cyclization at room temperature, representing a mild Csp3-H bond functionalization. The resulting spiro Meldrum's acid intermediates then underwent intramolecular Friedel-Crafts acylation, completing the one-pot, domino reaction. The reported protocol generates the 6-6-5-6 tetracyclic core of tetrahydrobenzo[b]fluoren-11-ones.

Oxaziridine-mediated intramolecular amination of sp3-hybridized c-h bonds

(Chemical Equation Presented) We describe a new oxaziridine-mediated approach to the amination of sp3-hybridized C-H bonds. In the presence of a copper(II) catalyst, N-sulfonyl oxaziridines participate in efficient intramolecular cyclization re