1309112-76-2Relevant academic research and scientific papers
Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase i inhibitors
Cheng, Pengfei,Zhu, Lingjian,Guo, Wei,Liu, Wenfeng,Yao, Jianzhong,Dong, Guoqiang,Zhang, Yongqiang,Zhuang, Chunlin,Sheng, Chunquan,Miao, Zhenyuan,Zhang, Wannian
, p. 437 - 442 (2012/08/28)
Structure modification of the side chain of the lead compound benzoxanthone provided a series of benzoxanthone analogues and 12 of them were first reported. The results showed that most of these compounds had moderate cytotoxicity against tumour cells with the 50% inhibition concentration in the micromolar range. Furthermore, benzoxanthone derivatives 5, 6c, 7a and 7e, showed potent topoisomerase I (Topo I) inhibitory effect and the results indicated that some compounds had potential for development as non-Camptothecin (CPT) topoisomerase I inhibitors.
