130916-48-2

Upstream product

• 615-36-1 2-bromoaniline 
• 88369-50-0 2-bromo-N-(2-bromophenyl)acetamide 
• 74255-21-3 2-hydroxybenzonitrile sodium salt 

Downstream Products

• 130916-58-4 3-Acetylamino-benzofuran-2-carboxylic acid (2-bromo-phenyl)-methyl-amide 
• 130916-57-3 3-Acetylamino-benzofuran-2-carboxylic acid (2-bromo-phenyl)-amide 
• 130940-75-9 N-(2-Bromophenyl)-N-methyl-3-amino-2-benzofurancarboxamide 
• 130916-51-7 N-(2-Bromophenyl)-N-methyl-2-<(2-cyanophenyl)oxy>acetamide 
• 130916-54-0 N-(2-Bromophenyl)-3-amino-2-benzofurancarboxamide 

Relevant academic research and scientific papers

Synthesis of New Arylbenzofurodiazepin-6-ones

Two new tetracyclic structures, containing the diazepine ring, were synthesized: 5,6-dihydro-12H-benzofurobenzodiazepin-6-one and 5,6-dihydro-12H-benzofuropyridodiazepin-6-one.Thus N-(2-haloaryl)-2-acetamides were cyclized to the corresponding N-(2-haloaryl)-3-amino-2-benzofurancarboxamides and then, through the formation of the central diazepine ring, to the title compounds.Formation of the diazepine ring took place only when an electron-withdrawing group was present in the molecule to facilitate the nucleophilic attack of an amine in the benzofuran intermediate.