130940-75-9Relevant academic research and scientific papers
Synthesis of New Arylbenzofurodiazepin-6-ones
Viti, Giovanni,Giannotti, Danilo,Nannicini, Rossano,Ricci, Renzo,Pestillini, Vittorio
, p. 1369 - 1375 (2007/10/02)
Two new tetracyclic structures, containing the diazepine ring, were synthesized: 5,6-dihydro-12H-benzofurobenzodiazepin-6-one and 5,6-dihydro-12H-benzofuropyridodiazepin-6-one.Thus N-(2-haloaryl)-2-acetamides were cyclized to the corresponding N-(2-haloaryl)-3-amino-2-benzofurancarboxamides and then, through the formation of the central diazepine ring, to the title compounds.Formation of the diazepine ring took place only when an electron-withdrawing group was present in the molecule to facilitate the nucleophilic attack of an amine in the benzofuran intermediate.
