130925-64-3Relevant academic research and scientific papers
A synthesis of pyrazolo [3, 4 - d] pyrimidine -4 - ketone compounds (by machine translation)
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Paragraph 0087-0089, (2018/09/02)
The invention provides a novel synthetic method for pyrazolo[3,4-d]pyrimidine-4-ketone compounds. The method employs reaction of hydrazine and methylene malononitrile with aldehyde to synthesize target compounds. The method has a reaction general formula
Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives
Liu, Ming-Xing,Li, Jia-Rong,Zheng, Kai,Yao, Huan,Zhang, Qi,Shi, Da-Xin
, p. 7658 - 7662 (2015/09/07)
An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition
Versatile synthesis of 6-alkyl/aryl-1H-pyrazolopyrimidin-4-ones
Reddy, K Hemender,Reddy, A Panduranga,Veeranagaiah, V
, p. 163 - 166 (2007/10/02)
Condensation of 5-amino-1H-pyrazole-4-carboxamide (1a) with various aromatic aldehydes furnishes 6-substituted-1H-pyrazolepyrimidin-4(5H)-ones (4a-f) via the intermediates 5-(N-arylideneamino)pyrazole-4-carboxamides (3a-f).Compounds 4a-f have also
STUDIES ON PYRAZOLOPYRIMIDINE DERIVATIVES. XVIII. FACILE PREPARATION OF 1H-PYRAZOLOPYRIMIDIN-4(5H)-ONES
Miyashita, Akira,Iijima, Chihoko,Higashino, Takeo,Matsuda, Hideaki
, p. 1309 - 1314 (2007/10/02)
Reaction of 5-amino-1-phenyl-1H-pyrazole-4-carboxamide (4) with the esters (3a-h) in the presence of sodium ethoxide in ethanol gave 1-phenyl-1H-pyrazolopyrimidin-4(5H)-one (1a) and its 6-substituted derivatives (1b-h).Similar treatment of 5-amino-1-methyl-1H-pyrazole-4-carboxamide (5) with 3a-h gave the 1-methyl-1H-pyrazolopyrimidin-4(5H)-ones (2a-h).
