130930-28-8

Basic information

• Product Name: Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate
• Synonyms: Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate;trans-1-Benzyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate
• CAS NO: 130930-28-8
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.31506
• Product Categories: pharmacetical
• Mol File: 130930-28-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate(130930-28-8)
• EPA Substance Registry System: Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate(130930-28-8)

Safety Data

• Hazardous Substances Data: 130930-28-8(Hazardous Substances Data)

Usage

General Description

Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate is a chemical compound that is used in organic synthesis and pharmaceutical research. It is a derivative of pyrrolidine, which is a five-membered heterocyclic compound containing a nitrogen atom. The "ethyl" group refers to the presence of an ethyl (C2H5) group in the compound. The "Cbz" group, also known as carboxybenzyl group, is a protective group used in organic chemistry. The 4-hydroxy-2-pyrrolidinecarboxylate moiety indicates the presence of a hydroxy group and a carboxylate group in the compound. Overall, this chemical has important applications in the development of pharmaceuticals and in the study of organic chemistry.

Upstream product

• 130830-64-7 N-(benzyloxycarbonyl)-trans-4-acetoxy-D-proline ethyl ester 

Downstream Products

• 130830-80-7 Mosher amide of cis-4-carboxy-D-proline dimethyl ester 
• 130830-72-7 N-(benzyloxycarbonyl)-cis-4-carboxy-D-proline dimethyl ester 
• 130830-68-1 N-(benzyloxycarbonyl)-cis-4-cyano-D-proline ethyl ester 
• 130830-76-1 N-(benzyloxycarbonyl)-cis-4-carboxy-D-proline 
• 130830-78-3 (2R,4R)-2,4-pyrrolidinedicarboxylic acid 
• 130830-62-5 N-(benzyloxycarbonyl)-trans-4-(tosyloxy)-D-proline ethyl ester 

Relevant articles and documents

Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer

In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.