130930-28-8 Usage
Uses
Used in Pharmaceutical Research:
Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate serves as a key building block for the creation of complex organic molecules. Its presence of the Cbz protective group makes it particularly useful in reactions where selective protection of functional groups is required.
Used in Medicinal Chemistry:
Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate is utilized as a chiral synthon in the design and synthesis of enantioselective pharmaceuticals. Its (S)-configuration provides a stereochemical advantage in the development of chiral drugs with improved efficacy and selectivity.
Used in Drug Development:
Ethyl (S)-1-Cbz-4-hydroxy-2-pyrrolidinecarboxylate is employed as a precursor in the preparation of bioactive molecules with potential applications in the treatment of various diseases. Its versatility in organic synthesis allows for the exploration of novel drug candidates with improved pharmacokinetic and pharmacodynamic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 130930-28-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,9,3 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 130930-28:
(8*1)+(7*3)+(6*0)+(5*9)+(4*3)+(3*0)+(2*2)+(1*8)=98
98 % 10 = 8
So 130930-28-8 is a valid CAS Registry Number.
130930-28-8Relevant academic research and scientific papers
Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer
Bridges, Richard J.,Stanley, Mark S.,Anderson, Michael W.,Cotman, Carl W.,Chamberlin, A. Richard
, p. 717 - 725 (2007/10/02)
In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.
