1309358-74-4

Basic information

• Product Name: N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide
• Synonyms: N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide
• CAS NO: 1309358-74-4
• Molecular Weight: 440.348
• Mol File: 1309358-74-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide(1309358-74-4)
• EPA Substance Registry System: N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide(1309358-74-4)

Safety Data

• Hazardous Substances Data: 1309358-74-4(Hazardous Substances Data)

Upstream product

• 104173-41-3 1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid 
• 501698-49-3 1-[3-(trifluoromethyl)-phenyl]cyclopropanecarbonyl chloride 
• 438019-67-1 [2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]amine 

Relevant articles and documents

Cyclopropyl carboxamides: A new oral antimalarial series derived from the Tres Cantos Anti-Malarial Set (TCAMS)

Rapid triaging of three series of related hits selected from the Tres Cantos Anti-Malarial Set (TCAMS) are described. A triazolopyrimidine series was deprioritized due to delayed inhibition of parasite growth. A lactic acid series has derivatives with IC50 50 = 3 nM) and has an oral bioavailability of 55% in CD-1 mice and an ED90 of 20 mg/kg after oral dosing in a nonmyelo-depleted P. falciparum murine model.