1309364-97-3

Upstream product

• 1309365-54-5 3-(2-amino-6-o-tolyl-1,7-naphthyridin-3-yl)-N-(3,3dimethylbutyl)acrylamide 
• 1309365-53-4 3-(2-amino-6-o-tolyl-1,7-naphthyridin-3-yl)acrylic acid 
• 1309365-52-3 methyl 3-(2-amino-6-o-tolyl-1,7-naphthyridin-3-yl)acrylate 
• 1309365-51-2 5-amino-2-o-tolylisonicotinaldehyde 
• 1309365-50-1 N-(4-formyl-6-o-tolylpyridin-3-yl)pivalamide 
• 93493-66-4 N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide 

Relevant academic research and scientific papers

AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer?s disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer?s Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I