1309368-10-2

Upstream product

• 1309367-81-4 2-(o-tert-butyl phenylsulfonylcarbamate)-1-m-tolylethanone 
• 1296783-60-2 3-m-tolyl-2H-1λ6-benzo[e][1,2]thiazine 1,1-dioxide 
• 1309367-95-0 C₂₀H₂₅NO₅S 
• 620-23-5 m-tolyl aldehyde 
• 310897-86-0 methyl o-tolylsulfonylcarbamate 
• 91340-63-5 N-(2-methylphenylsulfonyl)-N-(tert-butyl)amine 

Relevant academic research and scientific papers

Method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium

The invention provides a method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium. A catalysis system used in the method is a chiral diphosphine complexe. Corresponding chiral sulfanilamides are obtained through reduction and amination of a simple and easily available ketoamine substrate, and enantiomeric excess can reach 99%. The method is simple to operate, practical and feasible; raw materials are simple and easily available; the catalyst is commercially available; and reaction conditions are mild. Moreover, high enantioselectivity, good yield and environment friendliness are realized in synthesis of chiral sulfanilamides through asymmetric reduction and amination.

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Br?nsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enan

Enantioselective Pd-catalyzed hydrogenation of enesulfonamides

Asymmetric hydrogenation of cyclic enesulfonamides affords chiral cyclic sulfonamides using Pd(OCOCF3)2/diphosphine complexes as catalysts with up to 98% ee.