310897-86-0Relevant academic research and scientific papers
Novel Methods for the Facile Construction of 3,3-Disubstituted and 3,3-Spiro-2H,4H-benzo[e]1,2-thiazine-1,1-diones: Synthesis of (11S,12R,14R)-2-Fluoro-14-methyl-11-(methylethyl)spiro[4H-benzo[e]-1,2-thiazine- 3,2′-cyclohexane]-1,1-dione, an Agent for the Electrophilic Asymmetric Fluorination of Aryl Ketone Enolates
Liu, Zhaopeng,Shibata, Norio,Takeuchi, Yoshio
, p. 7583 - 7587 (2000)
Novel methods for the facile construction of 3,3-disubstituted and 3,3-spiro 2H,4H-benzo[e][1,2]-thiazine-1,1-diones 8a-h are described. o-Methyl lithiation of N-Boc-o-toluenesulfonamide 6 followed by reaction with a variety of ketones gave the corresponding carbinol sulfonamides 7a-g, which underwent cyclization under acidic (methanesulfonic acid) or neutral (NaI/TMSCl/MeCN) conditions to afford the sultams 8a-h in high yields. The chiral spiro sultams 8g,h were subjected to FClO3 fluorination to give the N-fluorosultams 11a,b, respectively, which were tested for electrophilic asymmetric fluorination of aryl ketone enolates. As a result, the N-fluorosultam 11a exhibited modest asymmetric inducing abilities with the highest ee, reaching 70% for enantioselective fluorination of the lithium enolate of 2-methyl-1-tetralone.
Synthesis of benzofused five-ring sultams via Rh-catalyzed C-H olefination directed by an N -Ac-substituted sulfonamide group
Li, Xueyuan,Dong, Yi,Qu, Fengyu,Liu, Gang
, p. 790 - 798 (2015/03/05)
A Rh-catalyzed N-Ac-sulfonamide group directed C-H olefination-cyclization to afford benzofused five-ring sultam is described with high yield and a wide range of substrate scope. The N-acetyl group is a key for this transformation implying that N-H acidit
Enantioselective IrI-catalyzed carbocyclization of 1,6-enynes by the chiral counterion strategy
Barbazanges, Marion,Auge, Mylene,Moussa, Jamal,Amouri, Hani,Aubert, Corinne,Desmarets, Christophe,Fensterbank, Louis,Gandon, Vincent,Malacria, Max,Ollivier, Cyril
experimental part, p. 13789 - 13794 (2012/01/06)
Enantioenriched bicyclo[4.1.0]hept-2-enes were synthesized by Ir I-catalyzed carbocyclization of 1,6-enynes. No chiral ligands were used, CO and PPh3 were the only ligands bound to iridium. Instead, the stereochemical information was
Excitatory amino acid receptor antagonists
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, (2008/06/13)
The present invention provides compounds of Formula I or Formula II, or the pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising compounds or Formula I or Formula II, and methods for treating neurological disorders and neurodegenerative diseases, particularly migraine.
