1309371-20-7

Basic information

• Product Name: (E)-1-(2-methoxyphenyl)-3-(2-nitrophenyl)prop-2-en-1-one
• Synonyms: (E)-1-(2-methoxyphenyl)-3-(2-nitrophenyl)prop-2-en-1-one
• CAS NO: 1309371-20-7
• Molecular Weight: 283.284
• Mol File: 1309371-20-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-methoxyphenyl)-3-(2-nitrophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-methoxyphenyl)-3-(2-nitrophenyl)prop-2-en-1-one(1309371-20-7)
• EPA Substance Registry System: (E)-1-(2-methoxyphenyl)-3-(2-nitrophenyl)prop-2-en-1-one(1309371-20-7)

Safety Data

• Hazardous Substances Data: 1309371-20-7(Hazardous Substances Data)

Upstream product

• 1015085-05-8 1-(2-methoxyphenyl)-2-(triphenyl-λ⁵-phosphaneylidene)ethan-1-one 
• 552-89-6 2-nitro-benzaldehyde 
• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 579-74-8 2-Methoxyacetophenone 

Downstream Products

• 1242160-43-5 C₁₆H₁₇NO 
• 72195-25-6 2-(2-methoxyphenyl)quinoline 
• 1452830-74-8 [1-benzyl-5-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl](2-methoxyphenyl)methanone 
• 1452830-86-2 [1-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactopyranos-6-yl)-5-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl](2-methoxyphenyl)methanone 

Relevant articles and documents

Visible-light driven synthesis of polycyclic benzo[: D] [1,3]oxazocine from 2-aminochalcone

Herein, we report a tandem cycloisomerization/nucleophilic addition/cyclization of 2-amino chalcone with bifunctional nucleophiles driven by visible light. This cascade process is realized by the irradiation of a blue LED at room temperature, which provides a concise route to structurally diverse benzo[d][1,3]oxazocine scaffolds. Mechanistic studies show that the reaction is initiated with the E to Z isomerization of a C-C double bond upon the irradiation of visible light, followed by cyclization/rearomatization to generate a transient quinolinium intermediate, which is trapped by the nucleophile and cyclized to produce the polycyclic benzo[d][1,3]oxazocine.

Organocatalytic enantioselective cascade aza-michael/michael addition for the synthesis of highly functionalized tetrahydroquinolines and tetrahydrochromanoquinolines

An efficient organocatalytic highly asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of tetrahydroquinolines and tetrahydrochromanoquinolines has been developed. This cascade reaction proceeds well at low catalyst loading with a broad substrate scope, furnishing the desired products in excellent yields with excellent diastereoselectivities and enantioselectivities (up to >99:1 dr, 99% ee) under mild conditions. Importantly, it is the first catalytic asymmetric method for tetrahydrochromanoquinolines. This protocol provides a straightforward entry to highly functionalized chiral tetrahydroquinoline and tetrahydrochromanoquinoline derivatives from simple starting materials. Copyright

Hydrogenation of ortho-nitrochalcones over Pd/C as a simple access to 2-substituted 1, 2, 3, 4-tetrahydroquinolines

The preparation of some 2-substituted-1, 2, 3, 4-tetrahydroquinoline has been achieved by the one-pot reductive intramolecular cyclization of ortho-nitrochalcones with gaseous hydrogen in the presence of a Pd/C catalyst and the best selectivity was observed using CH2Cl2 as solvent. The method is operationally simple and versatile since ortho-nitrocalchones are easily accessible by Claisen-Schmidt condensation of 2-nitrobenzaldehydes and enolizable ketones. Selected examples on structurally different substrates have been considered and a novel tetrahydroquinoline and a benzo[h]tetrahydroquinoline were prepared and characterised.