1309375-20-9Relevant academic research and scientific papers
A direct, efficient method for the preparation of siRNAs containing ribo-like north bicyclo[3.1.0]hexane pseudosugars
Terrazas, Montserrat,Avino, Anna,Siddiqui, Maqbool A.,Marquez, Victor E.,Eritja, Ramon
, p. 2888 - 2891 (2011/08/02)
An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2-O-(2-cyanoethoxymethyl) (CEM) and 2-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba- modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.
Practical synthetic routes to carbon-substituted nucleosides
Pryde, David C.,Middleton, Donald S.,Stephenson, Peter T.,Wainwright, Philip,Maddaford, Adrian,Zhang, Xiurong,Leese, David,Glen, Rebecca,Hart, James,Forrest, Neil,Guyot, Thierry
, p. 6415 - 6419 (2011/12/21)
Robust practical routes to three different carbon-substituted nucleosides are described. Short synthetic procedures for preparing 1-homonucleosides, 2'-C-methyl-carbanucleosides and 2'-C-methyl-cyclopro-pyl/cyclopentyl fused bicyclic ribose analogues are described starting from readily available building blocks. Crown Copyright
