303963-92-0

Usage

Uses

Used in Pharmaceutical Industry:
(3aR,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one is used as a building block in the synthesis of various biologically active compounds. Its protecting group allows for the controlled exposure of reactive sites, making it valuable for the development of new pharmaceuticals and complex organic molecules.
Used in Medicinal Chemistry:
(3aR,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one is utilized in medicinal chemistry for the synthesis of compounds with potential therapeutic applications. Its versatility and the ability to control the reactivity of the molecule make it a valuable tool in drug discovery and development.
Used in Organic Synthesis:
(3aR,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one is employed as a key intermediate in the synthesis of complex organic molecules. Its unique structure and the presence of a protecting group enable the selective formation of desired products, making it an important component in the field of organic synthesis.

InChI:InChI=1/C25H30O4Si/c1-24(2,3)30(19-12-8-6-9-13-19,20-14-10-7-11-15-20)27-17-18-16-21(26)23-22(18)28-25(4,5)29-23/h6-16,22-23H,17H2,1-5H3/t22-,23+/m1/s1

Upstream product

• 681853-92-9 (1R,4S,5S)-(+)-4,5-isopropylidenedioxy-1-(tert-butyldiphenylsilyloxymethyl)-2-cyclopenten-1-ol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 10257-32-6 D-ribose 
• 532-20-7 D-Ribose 
• 50-69-1 D-ribose 
• 902799-70-6 C₂₇H₃₆SiO₄ 
• 952418-10-9 (1R)-(+)-1-[(4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-1-[(tert-butyldiphenylsilyloxy)methyl]-2-propen-1-ol 
• 681853-95-2 (-)-1-[(4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-2-(tert-butyldiphenylsilyloxy)ethan-1-one 
• 681853-93-0 (1R)-(-)-1-[(4R,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-2-(tert-butyldiphenylsilyloxy)ethan-1-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 96690-02-7 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose 

Downstream Products

• 303963-93-1 (3aS,4S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol 
• 952418-11-0 (1R,4R,5S)-9-[3-(tert-butyldiphenylsilyloxymethyl)-4,5-isopropylidenedioxy-2-cyclopenten-1-yl]-N⁶,N⁶-bis(tert-butoxycarbonyl)adenine 
• 952418-12-1 (1R,4R,5S)-9-[3-(tert-butyldiphenylsilyloxymethyl)-4,5-isopropylidenedioxy-2-cyclopenten-1-yl]adenine 
• 72877-50-0 neplanocin A 
• 1281922-85-7 C₂₆H₃₆O₅SSi 
• 1281922-72-2 (4-tert-butoxy-2,2-dioxo-tetrahydro-2-yl-6-cyclopenta[1,3,2]-dioxathiol-5-ylmethoxy)-tert-butyl-diphenyl-silane 
• 1281922-74-4 6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-one 
• 905579-51-3 MLN4924 
• 1281922-73-3 3-tert-butoxy-4-(tert-butyldiphenylsilanyloxymethyl)-cyclopentane-1,2-diol 
• 1309375-19-6 C₁₈H₁₉N₃O₅ 
• 1309375-20-9 C₃₀H₄₅N₃O₆Si₂ 
• 1309375-22-1 C₂₂H₂₄N₄O₆ 
• 1309375-23-2 C₄₃H₄₂N₄O₈ 
• 1309375-24-3 C₅₂H₅₉N₆O₉P 

Relevant academic research and scientific papers

POLYMORPHIC COMPOUNDS AND USES THEREOF

The present invention provides compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS

The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder.

Compounds and methods for treating neurological and cardiovascular conditions

The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT

A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl: R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if

Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L

Histone methyltransferase DOT1L is a drug target for MLL leukemia. We report an efficient synthesis of a cyclopentane-containing compound that potently and selectively inhibits DOT1L (Ki = 1.1 nM) as well as H3K79 methylation (IC50 ～

Total syntheses of a conformationally locked North-type methanocarba puromycin analogue and a dinucleotide derivative

An original synthetic approach for the first synthesis of an enantiopure methanocarba puromycin (3'-α-aminoacylamino-3'-deoxyadenosine) analogue and its cytidine dinucleotide derivative is described. Each compound is conformationally locked in a North-typ

Synthesis of (-)-neplanocin A with the highest overall yield via an efficient Mitsunobu coupling

Neplanocin A was synthesized in very high isolated yield and purity, in 10 steps from d-ribose via an efficient Mitsunobu coupling using N6-bis-Boc-protected adenine. In fact, this synthesis is a short pathway to enantiopure neplanocin A giving

Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides

The preparative and stereoselective synthesis (45-50% overall yields, >50 g scale) of the key carbasugars 7a-d was achieved from D-ribose via stereoselective Grignard reaction and oxidative rearrangement as key reactions. Copyright Taylor & Francis, Inc.

Preparative and Stereoselective Synthesis of the Versatile Intermediate for Carbocyclic Nucleosides: Effects of the Bulky Protecting Groups to Enforce Facial Selectivity

The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the