130944-11-5

Upstream product

• 90-15-3 α-naphthol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 109-77-3 malononitrile 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 3785-90-8 2-(4-hydroxyphenylmethylene)malononitrile 

Downstream Products

• 1446242-92-7 4-(4-hydroxyphenyl)-2-oxo-2H-benzo[h]chromene-3-carbonitrile 
• 1393816-52-8 4-(8-amino-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-7-yl)phenol 

Relevant academic research and scientific papers

A one-pot green synthesis of 2-amino-4H-benzo[h]chromenes catalyzed by a dioxomolybdenum Schiff base complex supported on magnetic nanoparticles as an efficient and recyclable nanocatalyst

In this work, catalytic performance of a molybdenum Schiff base complex-supported magnetic support as a nanocatalyst was evaluated for the preparation of 2-amino-4H-benzo[h]chromenes through one-pot, three component reactions of 1-naphthol, various aldehydes, and malononitrile under solvent-free conditions. A promising greener and eco-friendly method with a short reaction time, high yield of products, and simple work-up procedure was achieved. The nanocatalyst could be easily separated and regenerated from reaction media by an external magnet and reused at least seven consecutive times with small drops in its catalytic performance.

An Eco-friendly Catalytic System for One-pot Multicomponent Synthesis of Diverse and Densely Functionalized Pyranopyrazole and Benzochromene Derivatives

An external base-free, efficient, cost-effective, and environmentally benign protocol has been developed for the one-pot multicomponent synthesis of highly functionalized pyranopyrazoles and benzochromenes using water extract of Agave americana (century p

Synthesis and characterization of sodium polyaspartate-functionalized silica-coated magnetite nanoparticles: A heterogeneous, reusable and magnetically separable catalyst for the solvent-free synthesis of 2-amino-4H-chromene derivatives

An efficient and facile method was used for the synthesis of sodium polyaspartate-functionalized silica-coated magnetite nanoparticles. The structure of this nanoparticle was characterized by scanning electron microscopies, X-ray diffraction, energy-dispe

A molybdenum(VI) Schiff base complex immobilized on functionalized Fe3O4 nanoparticles as a recoverable nanocatalyst for synthesis of 2-amino-4H-benzo[h]chromenes

A dioxomolybdenum(VI) complex of a Schiff base, immobilized on the surface of modified Fe3O4 with a silica coating, has been synthesized and characterized by spectroscopic and microscopic techniques including FTIR, TGA, ICP, SEM, EDX, VSM, and XRD analyses. The catalytic performance of this material has been evaluated for the preparation of 2-amino-4H-benzo[h]chromenes via the one-pot, three-component reaction of aldehydes, malononitrile, and 1-naphthol under solvent-free conditions. The benefits of this protocol are short reaction time, simple workup procedure, and high yields of products. Also, the synthesized nanocatalyst could be separated easily from the reaction mixture using an external magnet and reused for four consecutive times with only minor degradation of its catalytic performance.

Design, synthesis, biological evaluation and in silico molecular docking studies of novel benzochromeno[2,3-d]thiazolopyrimidine derivatives

Abstract: A new series of benzochromeno[2,3-d]thiazolopyrimidine derivatives were synthesized by involving 7-phenyl-10-thioxo-7,9,10,11-tetrahydro-8H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-ones with phenacyl bromide in the presence of p-toluenesulfonic acid

Aqua one-pot, three-component synthesis of dihydropyrano[3,2-c]chromenes and amino-benzochromenes catalyzed by sodium malonate

The widespread biological properties of dihydropyrano[3,2-c]chromenes, 2-amino-4-aryl-4H-benzo[h]chromenes, and 3-amino-1-aryl-1H-benzo[f]chromenes have led to increasing efforts for the development of tremendously effective synthetic protocols aimed at their synthesis. In this contribution, sodium malonate was employed for the first time as an efficient catalyst for the one-pot, three-component tandem Knoevenagel–cyclocondensation reaction of 4-hydroxycoumarin (or naphthols), malononitrile/ethyl cyanoacetate, and various aldehydes. These compounds underwent Knoevenagel–Michael–Thorpe–Ziegler cyclization upon heating at 70?°C in water to give the respective medicinally relevant dihydropyrano[3,2-c]chromenes and amino-benzochromenes. The method is versatile and amenable to many substrates as it requires no specialized devices such as microwave, ultrasound and ball-milling. Also, the salient features of this high-yielding protocol are green reaction conditions, the use of commercially available catalyst, easy purification processes by a simple filtration, and relatively shorter reaction times.

SBA-15@methenamine-HPA: a novel, simple, and efficient catalyst for one-pot three-component synthesis of 2-amino-4H-chromene derivatives in aqueous medium

Abstract: Cl-functionalized SBA-15 was reacted with methenamine and subsequently applied for embedding heteropolyacids. The novel catalyst, SBA-15@methenamine-HPA, was characterized by using scanning electron microscopy (SEM) with energy-dispersive X-ray

Aegle marmelos in heterocyclization: Greener, highly efficient, one-pot three-component protocol for the synthesis of highly functionalized 4 H -benzochromenes and 4 H -chromenes

A facile, one-pot three-component protocol for the synthesis of 2-amino-4H-chromene derivatives has been demonstrated using Bael Fruit Extract (BFE) as a natural catalyst in a green reaction medium. This method offers a mild, efficient and highly economic

One-pot catalytic multicomponent synthesis of chromene derivatives by 1-Allyl-3-Methyl-Imidazolium halides

2-amino-3-cyano-4-aryl-4H-benzo[h]chromenes and 2-amino-3- cyano-1-aryl-1H-benzo[f] chromenes were obtained in a one-pot three-component reaction of a or β-naphthol (1a and 1b), aromatic aldehydes (2a-n), malononitrile (3) in the presence of 1-allyl-3-met

Synthesis of 2-amino-3-cyano 4-H-chromenes containing quinoline in water: computational study on substituent effects

An efficient, high yielding and environmentally benign strategy to the synthesis of new 2-amino-3-cyano-4-H-chromene derivatives, via one-pot three-component reaction involving malononitrile, various α- or β-naphthol and appropriate aromatic aldehydes inc