130944-36-4

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 130944-46-6 4,4'-bis(methylthio)benzhydrylammonium 4-toluenesulfonate 
• 130944-45-5 4,4'-bis(methylthio)benzhydrylamine 
• 100-68-5 methyl-phenyl-thioether 
• 63084-99-1 bis(4-(methylthio)phenyl)methanone 

Downstream Products

• 141971-74-6 (S)-2-{(S)-1-[({[Bis-(4-methanesulfinyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-3-methyl-butylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 141971-73-5 {(S)-1-[({[Bis-(4-methanesulfinyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 130944-38-6 ({[Bis-(4-methanesulfinyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant academic research and scientific papers

A SAFETY-CATCH TYPE OF AMIDE PROTECTING GROUP

p-Substituted benzhydrylamine derivatives 1-4 were synthesized and evaluated for their lability towards various acids.The pair 2 and 4 seems to be suitable for peptide synthesis using the base labile Fmoc- and/or acid labile Boc-strategy.

"SAFETY-CATCH" PROTECTING GROUPS IN PEPTIDE SYNTHESIS

A new benzhydryl-type protective groups for amides based on the concept of converting a stable protecting group into a labile one (safety-catch principle) are described.The p-substituted benzhydrylamine derivatives III(a, b), IV(a, b) are shown to be labi