63084-99-1Relevant articles and documents
Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers
Delcaillau, Tristan,Boehm, Philip,Morandi, Bill
supporting information, p. 3723 - 3728 (2021/04/07)
We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.
Aggregation-induced emission molecular compound, preparation method and application thereof
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Paragraph 0124-0126; 0128, (2021/06/26)
The invention discloses an aggregation-induced emission molecular compound. The aggregation-induced emission molecular compound comprises a monosubstituted tetraphenyl ethylene derivative taking tetraphenyl ethylene as a skeleton, or a heavy atom-containi
Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate
Rérat, Alice,Michon, Christophe,Agbossou-Niedercorn, Francine,Gosmini, Corinne
, p. 4554 - 4560 (2016/09/23)
Symmetrical diaryl ketones were prepared by a cross-coupling reaction between aryl bromides and ethyl chloroformate. This new method, which uses a catalyst composed of CoBr2and a bipyridine ligand along with readily available starting materials, allows for the synthesis of a variety of symmetrical diaryl ketones in moderate to excellent yields (37–99 %) under mild conditions. This reaction, in which ethyl chloroformate acts as a surrogate of carbon monoxide in the presence of cobalt and zinc, represents an interesting alternative to previously known approaches for the synthesis of diarylmethanones.
Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4′-dimethylsulfinylbenzhydryl
Dekan, Zoltan,Mobli, Mehdi,Pennington, Michael W.,Fung, Eileen,Nemeth, Elizabeta,Alewood, Paul F.
supporting information, p. 2931 - 2934 (2014/04/03)
A safety-catch cysteine protecting group, S-4,4′- dimethylsulfinylbenzhydryl (Msbh), was designed and developed to expand the capabilities of synthetic strategies for the regioselective formation of disulfide bonds in cysteine-rich peptides. The directed regioselective synthesis of human hepcidin, which contains four disulfide bonds, was undertaken and led to a high-resolution NMR structure under more physiologically relevant conditions than previously. Conversely, hepcidin synthesized with the formerly assigned vicinal disulfide-bond connectivity displayed significant conformational heterogeneity under similar conditions. The two synthetic forms of human hepcidin induced ferroportin internalization with apparent EC 50 values of 2.0 (native fold, 1) and 4.4 nM (non-native fold, 2), with 2 undergoing isomerization to 1 in the presence of ferroportin expressing cells.
MERCAPTO-BENZOPHENONE COMPOUNDS, COMPOSITIONS AND PREPARATION METHODS THEREOF
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Paragraph 0059-0060, (2014/06/24)
The present invention provides a photocurable composition prepared using mercapto benzophenone compounds as key raw materials. The present invention aims to solve the problems existing in the prior photo-curing technology that low-molecular photoinitiator
Mercapto Benzophenone Compounds, Compositions and Preparation Method Thereof
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Paragraph 0101; 0102; 0103, (2013/06/27)
The present invention provides a photocurable composition prepared using mercapto benzophenone compounds as key raw materials. The present invention aims to solve the problems existing in the prior photo-curing technology that low-molecular photoinitiator
Ring contraction during the 6π-electrocyclisation of naphthopyran valence tautomers
Gabbutt, Christopher D.,Heron, B. Mark,Kolla, Suresh B.,Kilner, Colin,Coles, Simon J.,Horton, Peter N.,Hursthouse, Michael B.
scheme or table, p. 3096 - 3104 (2009/02/03)
The thermal and photochemical ring-opening of spiro(3H-naphtho[2,1-b]pyran- 3,9′-thioxanthene-10,10-dioxide) 3 results in the facile ring-contraction to 9-(naphtho[2,1-b]furan-2-yl)-9H-thioxanthene-10,10-dioxide 6. Similar behaviour is displayed by the is
Ferrocenyl compounds possessing protected phenol and thiophenol groups: Synthesis, X-ray structure, and in vitro biological effects against breast cancer
Heilmann, Julia B.,Hillard, Elizabeth A.,Plamont, Marie-Aude,Pigeon, Pascal,Bolte, Michael,Jaouen, Gérard,Vessières, Anne
, p. 1716 - 1722 (2008/09/18)
We have previously shown that conjugated ferrocenyl p-phenols show strong cytotoxic effects against both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cell lines, possibly via metabolic quinone methide (QM) formation. To fur
Expedient synthesis of symmetric aryl ketones and of ambient-temperature molten salts of imidazole
Lucas,El Mehdi,Ho,Belanger,Breau
, p. 1253 - 1258 (2007/10/03)
A short procedure for the synthesis of 2,2-di(3-thienyl)-1,3-dioxolan is described. The route developed is convenient (only two synthetic and one chromatographic steps are required) and efficient (66% overall yield from 3-bromothiophene). This compound was transformed into the ketone, cyclopenta[2,1-b:3',4'-b']dithiophen-4-one by a known process. Optimized syntheses of symmetric aryl ketones, 1-alkyl-3-methylimidazolium and 1-alkyl-2-methyl-3-methylimidazolium liquid salts are also reported.
"SAFETY-CATCH" PROTECTING GROUPS IN PEPTIDE SYNTHESIS
Patek, Marcel,Lebl, Michal
, p. 508 - 524 (2007/10/02)
A new benzhydryl-type protective groups for amides based on the concept of converting a stable protecting group into a labile one (safety-catch principle) are described.The p-substituted benzhydrylamine derivatives III(a, b), IV(a, b) are shown to be labi