1309477-83-5Relevant academic research and scientific papers
Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: Alleviating drug-drug interactions through use of pubchem data and comparative molecular field analysis guided synthesis
Wendt, Bernd,Mülbaier, Marcel,Wawro, Sabine,Schultes, Christoph,Alonso, Jorge,Janssen, Bernd,Lewis, Joe
, p. 3982 - 3986 (2011/08/05)
Inhibitors of hypoxia-inducible factor 1 (HIF-1) represent promising anticancer therapeutics. We have identified a series of potent toluidinesulfonamide HIF-1 inhibitors. However, the series was threatened by a potential liability to inhibit CYP2C9 which could cause dangerous drug-drug interactions when being coadministered with other drugs. We used structure-activity data from the PubChem database to develop a topomer CoMFAmodel that guided the design of novel sulfonamides with high selectivity for HIF-1 over CYP2C9 inhibition.
