130948-34-4

Basic information

• Product Name: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol
• Synonyms: 2-furanmethanol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydro-, (2S,5R)-; 4-Amino-1-(2,3-dideoxy-.beta.-D-glycero-pentofuranosyl)-1H-imidazo[4,5-c]pyridine; 4-Amino-1-(2,3-dideoxy-beta-D-glycero-pentofuranosyl)-1H-imidazo(4,5-c)pyridine
• CAS NO: 130948-34-4
• Molecular Formula: C₁₁H₁₄N₄O₂
• Molecular Weight: 234.2545
• Mol File: 130948-34-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 532.4°C at 760 mmHg
• Flash Point: 275.8°C
• Density: 1.61g/cm³
• Vapor Pressure: 3.64E-12mmHg at 25°C
• Refractive Index: 1.762
• CAS DataBase Reference: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(130948-34-4)
• EPA Substance Registry System: [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol(130948-34-4)

Safety Data

• Hazardous Substances Data: 130948-34-4(Hazardous Substances Data)

Usage

General Description

The chemical "[(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol" is a compound that contains a tetrahydrofuran ring substituted with a 4-amino-1H-imidazo[4,5-c]pyridine moiety and a methanol group. The 4-amino-1H-imidazo[4,5-c]pyridine moiety is a fused imidazole and pyridine ring system with an amino group at the 4-position, while the tetrahydrofuran ring is a five-membered heterocyclic ring containing four carbon atoms and one oxygen atom. The methanol group is a simple alcohol with a hydroxyl group attached to a methylene group. [(2S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)tetrahydrofuran-2-yl]methanol may have potential applications in medicinal chemistry, such as in the development of pharmaceutical drugs or in biochemical research.

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 78582-13-5 4-Chloro-1-<2-deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 131425-01-9 4-chloro-1-(2',3'-dideoxy-5'-O-<(1'',1 ''-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 78582-15-7 4-chloro-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 130948-31-1 4-Chloro-1-<2-deoxy-5-O-(4-methoxytrityl)-3-O-phenoxy(thiocarbonyl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 130948-30-0 4-Chloro-1-<2-deoxy-5-O-(4-methoxytrityl)-β-D-erythropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 130948-32-2 4-Chloro-1-<2,3-dideoxy-5-O-(4-methoxytrityl)-β-D-glyceropentofuranosyl>-1H-imidazo<4,5-c>pyridine 
• 221459-89-8 (2RS,5S)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>tetrahydrofuran-2-ol 
• 131487-19-9 2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-α/β-D-glycero-pentofuranosyl chloride 
• 130948-33-3 4-chloro-1-(2',3'-dideoxy-β-D-glycero-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 2770-01-6 4-chloro-1H-imidazo[4,5-c]pyridine 

Downstream Products

• 214121-87-6 2,3-dideoxyribofuranose 
• 6811-77-4 3-deazaadenine 

Relevant articles and documents

Purine analog nucleoside and nucleotide compounds

The invention concerns nucleoside derivatives of the formula I STR1 in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) group substituted by R1, R2 and R3, in which R1, R2 and R3, which can be the same or different, signify hydrogen, halogen, a C1 -C7 -alkyl, C2 -C7 -alkenyl, hydroxy, mercapto, C1 -C7 -alkylthio, C1 -C7 -alkoxy, C2 -C7 -alkenyloxy, ar-C1 -C5 -alkyl, ar-C2 -C5 -alkenyl, ar-C1 -C5 -alkoxy, ar-C2 -C5 -alkenyloxy, aryloxy, nitro, amino-C1 -C7 -alkyl, C1 -C7 -alkylamino-C1 -C7 -alkyl, di-C1 -C7 -alkylamino-C1 -C7 -alkyl, amino, a substituted amino group --NMR4 or --N(R4)2 or an imino group --N=CH--R4, and R4 has the meaning given in the description, R5, R6, R7 and R8 each signify hydrogen or one or two of the radicals R5, R6, R7 and R8 a hydroxyl, halogen, cyano, azido or a substituted amino group --NHR4 or --N(R4)2 or R5 and R7 can together represent a further bond between C-2' and C-3' and Y represents hydrogen or a C1 -C7 -alkylcarbonyl, monophosphate, diphosphate or triphosphate group, whereby "aryl" signifies a phenyl or naphthyl group and "hetaryl" a furanyl, thienyl or pyridyl group, as well as their possible anomers, N7 - or N9 -regioisomers (purine nomenclature), tautomers and salts.

Synthesis of 2,3-dideoxy-3-deazaadenosine and some of its analogues

-