130948-80-0Relevant academic research and scientific papers
Substituierte Methylphosphonate als Synthone fuer alicyclische α-funktionalisierte Phosphonate
Neidlein, Richard,Eichinger, Thomas
, p. 1037 - 1044 (2007/10/02)
Syntheses of cycloalkylphosphonates 4, and 6-8 are described, starting from the substituted methylphosphonates 1-3.Hydrolysis of the phosphonic esters 4 and 8 yield the free phosphonic acids 5 and 10; the partial hydrolysis of 7 leads to easily accessible 9.The benzo condensed phosphonates 12 and 13 are formed according to the solvent; a higher boiling medium should be used to obtain 15 and 17. Keywords: Phosphonates; Cycloalkylation and benzo condensed cycloalkylation.
RECENT WORK ON THE SYNTHESIS OF PHOSPHONATE-CONTAINING, BONE-ACTIVE HETEROCYCLES
Ebetino, Frank H.,Degenhardt, Charles R.,Jamieson, Laura A.,Burdsall, Don C.
, p. 855 - 862 (2007/10/02)
New approaches to the design and synthesis of bone antiresorptive phosphonates have led to the discovery of the cyclic bisphosphonate series and the phosphonoalkylphosphinate heterocyclic series.The latter class, which offers substrates for interesting dianion chemistry, has been shown to include effective bone-active isosteres of the well known bisphosphonates.
α-FUNCTIONAL CYCLOALKYLPHOSPHONATES. I. SYNTHESIS
Nasser, Jamal,About-Jaudet, Elie,Collignon, Noel
, p. 171 - 179 (2007/10/02)
Cycloalkylphosphonates 2 of different sizes (from cyclopropyl to cycloheptyl) bearing various functional groups Z in α-position were synthesized by bis-alkylation of α-functional methylphosphonates 1 and ω-dibromoalkanes in presence of base.The choice of the basic system is determined by the nature of Z.With powerful electron-withdrawing groups, NaH-THF/DMSO (Method A, for Z = CN, SO2R) or liquid-solid phase transfer process proved to be the more suitable systems.For Z = aryl or SR, lithium diisopropylamide is required to achieve the deprotonation.A wide range of new phoshonates were obtained in high yields on preparative scale.
