1309658-35-2Relevant academic research and scientific papers
Catalytic asymmetric synthesis of trisubstituted aziridines
Huang, Li,Wulff, William D.
, p. 8892 - 8895 (2011/08/04)
A method is described which provides for the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds. While unactivated imines were not reactive to α-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with both α-diazo esters and α-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectivities.
