1309675-40-8Relevant academic research and scientific papers
Formal synthesis of leustroducsin B via Reformatsky/Claisen condensation of silyl glyoxylates
Greszler, Stephen N.,Malinowski, Justin T.,Johnson, Jeffrey S.
supporting information; experimental part, p. 3206 - 3209 (2011/08/07)
A formal synthesis of leustroducsin B has been completed. The synthesis relies upon a recently developed Reformatsky/Claisen condensation of silyl glyoxylates and enantioenriched β-lactones that establishes two of the molecule's three core stereocenters and permits further elaboration to an intermediate in Imanishi's synthesis via reliable chemistry (Prasad reduction, asymmetric pentenylation, Mitsunobu inversion).
Remote stereoinduction in the acylation of fully substituted enolates: Tandem reformatsky/quaternary claisen condensations of silyl glyoxylates and β-lactones
Greszler, Stephen N.,Malinowski, Justin T.,Johnson, Jeffrey S.
supporting information; experimental part, p. 17393 - 17395 (2011/02/23)
Reformatsky reagents react sequentially with silyl glyoxylates and β-lactones to give highly functionalized Claisen condensation products. A heretofore undocumented instance of stereochemical 1,4-induction results in efficient transmission of β-lactone st
