130981-53-2

Upstream product

• 100-46-9 benzylamine 
• 81801-09-4 4-O-benzyl-2,3-O-isopropylidene-D-threose 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 130914-05-5 (4R,5R)-4-Benzyliminomethyl-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 139056-96-5 (4R,5R)-4-<(R)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 139056-97-6 (2R,3R,4R)-4-(N-Benzyl-N-methoxycarbonyl)amino-1-benzyloxy-5-cyclohexylpentane-2,3-diol 
• 130914-08-8 (4R,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one 
• 130914-07-7 (4R,5R)-3-Benzyl-5-((S)-2-benzyloxy-1-hydroxy-ethyl)-4-cyclohexylmethyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could

A stereoselective synthesis of cyclohexylnorstatine, the key component of a renin inhibitor

The title synthesis could be accomplished by employing the novel addition reaction of a Grignard reagent with an imine in the presence of cerium(III) chloride.