Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

DOI: 10.1248/cpb.39.2550

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2550 - 2555 (1991)

Update date:2022-07-29

Topics: Synthesis Chiral Experimental Renin inhibitors C-Terminal Component

Authors:

Kobayashi

Matsumoto

Takemoto

Nakatani

Ito Ito

Kamijo Kamijo

Harada Harada

Terashima

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Article abstract of DOI:10.1248/cpb.39.2550

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could

Full text of DOI:10.1248/cpb.39.2550

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