130985-42-1

Basic information

• Product Name: ethyl 3-(tert-butoxycarbonylaMino)-3-Methylbutanoate
• Synonyms: ethyl 3-(tert-butoxycarbonylaMino)-3-Methylbutanoate;3-(Boc-amino)-3-methylbutanoic acid ethyl ester
• CAS NO: 130985-42-1
• Molecular Formula: C₁₂H₂₃NO₄
• Molecular Weight: 245.31532
• Mol File: 130985-42-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.011±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.35±0.46(Predicted)
• CAS DataBase Reference: ethyl 3-(tert-butoxycarbonylaMino)-3-Methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(tert-butoxycarbonylaMino)-3-Methylbutanoate(130985-42-1)
• EPA Substance Registry System: ethyl 3-(tert-butoxycarbonylaMino)-3-Methylbutanoate(130985-42-1)

Safety Data

• Hazardous Substances Data: 130985-42-1(Hazardous Substances Data)

Usage

General Description

Ethyl 3-(tert-butoxycarbonylamino)-3-methylbutanoate is a chemical compound commonly used as a building block in organic synthesis. It is a derivative of the amino acid valine, and is often employed in the synthesis of peptides and proteins. The tert-butoxycarbonyl (Boc) protecting group on the amino group of valine allows for selective manipulation of the molecule during synthesis, and the ethyl ester group enhances the compound's solubility and reactivity. Ethyl 3-(tert-butoxycarbonylamino)-3-methylbutanoate is a valuable tool in the development of new pharmaceuticals and bioactive molecules, as well as in the study of protein structure and function.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 85532-40-7 Ethyl 3-amino-3-methylbutanoate hydrochloride salt 
• 638-10-8 ethyl 3-methylbut-2-enoate 
• 85532-42-9 ethyl 3-amino-3-methylbutanoate 

Downstream Products

• 130985-44-3 N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 130985-46-5 N-α--L-phenylalanyl>-N^α-methyl-L-histidyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine 
• 130985-45-4 N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 135378-86-8 C₅₃H₈₁N₇O₉S 
• 135378-87-9 [2-((S)-1-{[(S)-1-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-((S)-2-methyl-butylcarbamoyl)-hexylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethylcarbamoyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester 
• 135378-56-2 (2S,4S,5S)-5-[(S)-2-{[(S)-2-(3-Amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-methyl-amino}-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid ((S)-2-methyl-butyl)-amide 
• 130985-58-9 N-α-(β-L-valyl)-L-phenylalanyl-N^α-methyl-L-histidyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine tris(trifluoroacetate) 
• 130985-57-8 N-α-(β-L-valyl-L-phenylalanyl)-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine tris(trifluoroacetate) 

Relevant articles and documents

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys

We previously reported that Boc-Pro-Phe-N-MeHis-Leuψ[CHOHCH2]-Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to resist degradation by selected proteases and a rat liver homogenate. It was shown to inhibit p