135378-56-2

Upstream product

• 135378-85-7 [(S)-1-({(S)-1-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-((S)-2-methyl-butylcarbamoyl)-hexylcarbamoyl]-2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethyl}-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 125907-78-0 (2S,4S,5S)-5-{(S)-2-[((S)-2-Amino-3-phenyl-propionyl)-methyl-amino]-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid ((S)-2-methyl-butyl)-amide 
• 129765-95-3 3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid 
• 638-10-8 ethyl 3-methylbut-2-enoate 
• 135378-87-9 [2-((S)-1-{[(S)-1-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-((S)-2-methyl-butylcarbamoyl)-hexylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethylcarbamoyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester 
• 130985-42-1 ethyl 3-<(butyloxycarbonyl)amino>-3-methylbutanoate 

Relevant academic research and scientific papers

Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys

We previously reported that Boc-Pro-Phe-N-MeHis-Leuψ[CHOHCH2]-Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to resist degradation by selected proteases and a rat liver homogenate. It was shown to inhibit p