1309860-93-2Relevant academic research and scientific papers
Synthesis method of 1, 5-diene derivative
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Paragraph 0034-0040, (2020/08/18)
The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry, and provides a preparation method of a 1, 5-diene derivative. The method comprises thefollowing steps: taking aryl substituted propyne and allyl boron ester as reaction raw materials, adopting 2-10mol% of a palladium catalyst, adding 2mol%-20mol% of acid and 100mol%-300mol% of alcoholas additives, and performing heating and stirring in an organic solvent for a certain period of time to generate the 1, 5-diene compound. The method disclosed by the invention has the beneficial effects that the operation is simple and convenient, the condition is mild, the method is environment-friendly, the catalyst can be recycled, the possibility of industrialization is realized, and the 1, 5-diene compound is obtained at a relatively high yield; and the 1, 5-diene compound synthesized by the method can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.
An easy access to styrenes: Trans aryl 1,3-, 1,4- and 1,5-dienes, and 1,3,5-trienes by Hiyama cross-coupling catalyzed by palladium nanoparticles
Chatterjee, Tanmay,Dey, Raju,Ranu, Brindaban C.
experimental part, p. 1103 - 1110 (2011/07/08)
A convenient and efficient procedure has been developed for the vinylation of aryl-, styrenyl-, cinnamyl- and dienyl-halides by a Pd(0) nanoparticle-catalyzed Hiyama cross-coupling to provide the corresponding dienes and trienes in high yields. The reaction does not require any ligand or co-catalyst, and is carried out using PdCl2 and tetrabutyl ammonium fluoride (TBAF) in THF. Pd nanoparticles are generated in situ and are the active catalytic species in this reaction. A wide range of functionalized styrenes, trans aryl 1,3-, 1,4- and 1,5- dienes, 1,2-, 1-3 and 1,4-bis(1,3-dienes), and 1,3,5-trienes can be obtained by this procedure. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2011.
