2809-65-6

Usage

Uses

Used in Pharmaceutical Industry:
BENZENE,1-CHLORO-4-(1-PROPY) is used as a chemical intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine and healthcare.
Used in Pesticide Production:
In the agricultural sector, BENZENE,1-CHLORO-4-(1-PROPY) serves as a crucial ingredient in the production of certain pesticides. Its role in creating effective pest control solutions helps protect crops and ensure food security.
Used in Dye Manufacturing:
BENZENE,1-CHLORO-4-(1-PROPY is also utilized in the manufacturing of dyes, where it contributes to the creation of a wide range of colors used in various industries, such as textiles, printing, and plastics.
Used as a Solvent:
BENZENE,1-CHLORO-4-(1-PROPY) is employed as a solvent in certain chemical processes. Its ability to dissolve other substances makes it a valuable asset in the production and processing of various compounds.
Used in Organic Synthesis:
As an organic synthesis compound, BENZENE,1-CHLORO-4-(1-PROPY) is involved in the creation of other chemical compounds, playing a significant role in the development of new materials and products across different industries.

Upstream product

• 106-39-8 bromochlorobenzene 
• 18295-60-8 propargyl magnesium bromide 
• 873-73-4 4-n-chlorophenylacetylene 
• 77-78-1 dimethyl sulfate 
• 6285-05-8 4'-chloropropiophenone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 74-99-7 prop-1-yne 
• 74-88-4 methyl iodide 
• 1245898-38-7 1-(1,1-diiodoprop-1-en-2-yl)-4-chlorobenzene 
• 99-91-2 para-chloroacetophenone 
• 127042-57-3 1-(1,1-dibromoprop-1-en-2-yl)-4-chlorobenzene 
• 70090-69-6 1-chloro-4-(prop-2-yn-1-yl)benzene 
• 16466-97-0 1-propynylmagnesium bromide 
• 3157-65-1 N-(p-chlorobenzylidene)-p-toluenesulfonamide 

Downstream Products

• 33649-40-0 2,4,6-Trinitro-benzenesulfonic acid (E)-1-(4-chloro-phenyl)-2-phenylsulfanyl-propenyl ester 
• 1879-52-3 cis-4-chloro-β-methylstyrene 
• 18826-55-6 2-p-Chlorphenyl-3-methyl-2-cyclopropen-1-carbonsaeure 
• 69645-14-3 2-p-Chlorphenyl-3-methyl-2-cyclopropen-1-carbonsaeuremethylester 
• 340020-33-9 1,1-dimethoxy-1-(p-chlorophenyl)propane 
• 66482-27-7 cis-2-Brom-1-p-chlorphenyl-1-propen 
• 87506-06-7 2-(4-chlorophenyl)-3-methyl-2-cyclopenten-1-one 
• 1193110-97-2 (2Z,4E)-3-acetyl-4-(4-chlorophenyl)-2,4-hexadien-2-ol 

Relevant academic research and scientific papers

Copper-Catalyzed Synthesis of Tetrasubstituted Alkenes via Regio- and anti-Selective Addition of Silylboronates to Internal Alkynes

As a new and complementary method for the synthesis of structurally defined tetrasubstituted alkenes, a copper-catalyzed regio- and anti-selective addition of silylboronates to unsymmetric internal alkynes has been developed. A variety of unactivated alky

Regio- And stereoselective electrochemical synthesis of sulfonylated enethers from alkynes and sulfonyl hydrazides

An electrooxidative direct difunctionalization of internal alkynes with sulfonyl hydrazides has been developed for the construction of sulfonated enethers. In this transformation, metal catalysts or stoichiometric amount of oxidants are not required and molecular nitrogen and hydrogen are the sole byproducts, providing a simple and green approach for preparing various sulfonyl tetrasubstituted alkenes. Notably, the protocol could be efficiently scaled up and the follow-up procedures of the corresponding functionalized alkenes demonstrate the practicality of the electrochemical synthesis.

Enantioselective Resolution Copolymerization of Racemic 2,3-Disubstituted cis-Epoxides with CO2 Mediated by Binuclear Cobalt(III) Catalyst?

Enantioselective resolution copolymerization of racemic internal epoxides with carbon dioxide (CO2) is a challenging issue because of their poor reactivity and complicated regio/stereoselectivity. Herein, we describe the first enantioselective

Enantioselective Addition of α-Nitroesters to Alkynes

By using Rh–H catalysis, we couple α-nitroesters and alkynes to prepare α-amino-acid precursors. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne undergoes isomerization to generate a RhIII–π-allyl electrophile, which is trapped by an α-nitroester nucleophile. A subsequent reduction with In powder transforms the allylic α-nitroesters to the corresponding α,α-disubstituted α-amino esters.

Rh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters

A highly enantioselective hydrogenation of α,β-unsaturated boronate esters catalyzed by Rh-(S)-DTBM-Segphos complex has been developed. Both (Z)-α,β- and β,β-disubstituted substrates can be successfully hydrogenated to afford chiral boronates with excellent enantioselectivities, up to 98 % ee. Furthermore, the obtained chiral boronate esters, as important versatile synthetic intermediates are successfully transformed to the corresponding chiral alcohols, amines and other important derivatives with maintained enantioselectivities.

Palladium-catalyzed methylation of terminal alkynes

In this communication, a palladium-catalyzed procedure for the methylation of terminal alkynes has been developed. With N,N,N-trimethylbenzenaminium trifluoromethanesulfonate as the methyl source, various desired products were obtained in moderate to good yields. Both aromatic and aliphatic alkynes are applicable.

Direct Synthesis of 1-Arylprop-1-ynes with Calcium Carbide as an Acetylene Source

A simple method is described for the synthesis of 1-arylprop-1-ynes directly from aromatic aldehyde p -tosylhydrazones by using calcium carbide as an acetylene source. The salient features of this protocol are its use of a readily available and easily handled source of acetylene, its operational simplicity, its high yield, and its broad substrate scope.

A Pd-catalyzed domino Larock annulation/dearomative Heck reaction

A palladium-catalyzed domino Larock annulation/dearomative Heck reaction is developed, which delivers a range of tetracyclic indoline derivatives in moderate to excellent yields through a Larock annulation of N-bromobenzoyl o-iodoanilines with alkynes and a subsequent intramolecular dearomative Heck reaction. This protocol provides a straightforward route to structurally diverse indolines from readily available starting materials by forming two new rings and three chemical bonds in a single step.

Multi-Metal-Catalyzed Oxidative Radical Alkynylation with Terminal Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation

A new way for C(sp3)-C(sp) cross-coupling with terminal alkynes has been developed by using a multi-metal-catalyzed reaction strategy. Alkyl radicals generated from different approaches are able to couple with terminal alkynes by judicious selection of the catalyst combination. This reaction protocol offers an efficient alternative approach for the synthesis of substituted alkynes from terminal alkynes besides traditional Sonogashira coupling. Mechanistic studies have also been carried out to clarify the role of each metal catalyst in the radical alkynylation processes. The reactions were found to go through radical reaction pathways. Synergistic cooperation of the metal catalysts is the key for controlling the reaction selectivity of alkyl radicals toward C(sp3)-C(sp) bond formation.

Trimethylsilyl-Protected Alkynes as Selective Cross-Coupling Partners in Titanium-Catalyzed [2+2+1] Pyrrole Synthesis

Trimethylsilyl (TMS)-protected alkynes served as selective alkyne cross-coupling partners in titanium-catalyzed [2+2+1] pyrrole synthesis. Reactions of TMS-protected alkynes with internal alkynes and azobenzene under the catalysis of titanium imido comple