1309873-33-3Relevant academic research and scientific papers
Direct conjugate alkylation of α,β-unsaturated carbonyls by TiIII-catalysed reductive umpolung of simple activated alkenes
Bichovski, Plamen,Haas, Thomas M.,Keller, Manfred,Streuff, Jan
, p. 5673 - 5682 (2016)
The titanium(iii)-catalysed cross-selective reductive umpolung of Michael-acceptors represents a unique direct conjugate β-alkylation reaction. It allows the cross-selective preparation of 1,6- and 1,4-difunctionalised building blocks without the requirement of stoichiometric organometallic reagents. In this full paper, the development and scope of the titanium(iii)-catalysed cross-selective reductive umpolung of Michael-acceptors is described. Based on the observed selectivities and additional mechanistic experiments a refined mechanistic proposal is presented.
A titanium(III)-catalyzed redox umpolung reaction for the reductive cross-coupling of enones with acrylonitriles
Streuff, Jan
supporting information; experimental part, p. 5507 - 5510 (2011/06/21)
Titanium does the job: 1,6-Difunctionalized alkyl units, which are traditionally hard to access, have been successfully obtained through a reductive cross-coupling of activated alkenes catalyzed by TiIII. A plausible reaction mechanism that pro
