126-98-7 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 126-98-7 differently. You can refer to the following data:
1. CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID
2. Methylacrylonitrile is a colorless liquid with
an odor like bitter almonds. It is reported that methacrylonitrile cannot be detected by its smell even at concentrations which are already dangerous for humans. Hence,
special attention must be given to ventilation and
estimations of the amount of poison present must be carried
out frequently.
Uses
Different sources of media describe the Uses of 126-98-7 differently. You can refer to the following data:
1. Methylacrylonitrile is used to make coating and elastomers and as an intermediate in the preparation of acids, amine, amides, and esters.
2. This study reports the toxicity and metabolism of Methacrylonitrile (MeAN) in normal male Sprague-Dawley rats and those pre-treated with caffeine, alcohol or both. These results suggest that caffeine inhibited and alcohol enhanced toxicity and metabolism of MeAN.
3. In preparation of homopolymers and copolymers; as an intermediate in the preparation of acids, amides, amines, esters, nitriles.
Production Methods
Methyl acrylonitrile can be derived from isobutyraldehyde.
General Description
A clear colorless liquid. Less dense than water. Flash point 55°F. Boiling point 195°F. Very be toxic by ingestion, inhalation and skin absorption. Used to make plastics and coatings.
Air & Water Reactions
Highly flammable. Soluble in water.
Reactivity Profile
METHACRYLONITRILE is a colorless, flammable, toxic liquid. Explosive in the form of vapor when exposed to heat, flame or sparks. When heated to decomposition Methacrylonitrile emits toxic fumes of nitrile and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 829].
Hazard
Flammable. Toxic by ingestion, inhalation,
and skin absorption.
Health Hazard
Different sources of media describe the Health Hazard of 126-98-7 differently. You can refer to the following data:
1. A lacrimator (causes tearing); an insidious poison which causes delayed skin reactions. Very readily absorbed through skin. Highly toxic.
2. Methylacrylonitrile is a moderate to severe acute toxicant. The degree of toxicity varied with toxic routes and species. Inhalation, ingestion, and skin application on test subjects produced convulsion. Exposure to high concentrations can result in asphyxia and death. The lethal concentrations varied among species from 50 to 400 ppm over a 4- hour exposure period. The clinical symptoms observed in rats suggested a toxic activity of metabolically formed cyanide (Peter and Bolt 1985). This finding was in contrast with acrylonitrile toxicity in the same species, where formation of metabolic cyanide played a minor role. Methylacrylonitrile is a mild skin and eye irritant. However, it is readily absorbed by skin. It showed delayed skin reaction. In mice, the lethal dose from intraperitoneal administration was 15 mg/kg. The oral toxicity due to this compound was also relatively high; an LD50 of 11.6 mg/kg was determined in mice. There is no report of its mutagenic, teratogenic, or carcinogenic actions in animals or humans. 4-Dimethylaminophenol plus sodium thiosulfate or Nacetylcystein was shown to antagonize the acute toxicity of methylacrylonitrile (Peter and Bolt 1985).
Fire Hazard
Methacrylonitrile evolves flammable concentrations of vapor at temperatures down to 55.04F. Thus, at room temperatures, flammable concentrations are liable to be present. Toxic fumes of nitrogen oxides are released when the material burns. Also, the chemical will explode due to its tendency to polymerize violently. Avoid heat. Hazardous polymerization may occur.
Safety Profile
Poison by ingestion,
inhalation, skin contact, and intraperitoneal
routes. An eye irritant. A dangerous fire
hazard when exposed to heat, flame, or
sparks. When heated to decomposition it
emits toxic fumes of NOx and CN-. See also
NITRILES.
Potential Exposure
This material is used as a monomer
in the preparation of polymeric coatings and elastomers
Shipping
UN3079 Methacrylonitrile, stabilized, Labels:
6.1; Hazard class: 6.1, 3-Flammable liquid, Inhalation
Hazard Zone B.
Purification Methods
Wash it with saturated aqueous NaHSO3 (to remove inhibitors such as p-tert-butylcatechol), 1% NaOH in saturated NaCl and then with saturated NaCl. Dry it with CaCl2 and fractionally distil it under nitrogen to separate it from impurities such as methacrolein and acetone. [Beilstein 2 IV 1539.]
Incompatibilities
May form explosive mixture with air.
Methacrylonitrile evolves flammable concentrations of
vapor at temperatures down to 12.8C. Thus, at room temperatures, flammable concentrations are liable to be present. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, aliphatic amines, alkanolamines, alkali,
and light. Heat sensitive; polymerization may occur due
to elevated temperature, visible light, or contact with
a concentrated alkali. Note: Typically contains 50 pm of monoethyl ether hydroquinone (662-62-8) as an inhibitor
to prevent polymerization.
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform to EPA regulations governing
storage, transportation, treatment, and waste disposal. Add
alcoholic NaOH, then oxidize with sodium hypochlorite.
After reaction, flush to sewer with water
Check Digit Verification of cas no
The CAS Registry Mumber 126-98-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 126-98:
(5*1)+(4*2)+(3*6)+(2*9)+(1*8)=57
57 % 10 = 7
So 126-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N/c1-4(2)3-5/h1H2,2H3
126-98-7Relevant articles and documents
Synthesis and properties of bis(biphenyl)chromium(i) 1,4-di(2- cyanoisopropyl)-1,4-dihydrofulleride and 1-(2-cyanoisopropyl)-1,2- dihydrofullerene
Markin,Shevelev,Domrachev,Fukin,Baranov,Lopatin,Kuropatov,Kirillov,Shavyrin,Kurskii
, p. 1970 - 1974 (2008)
Radical-ion salts bis(biphenyl)chromium(i) 1,4-di(2-cyanoisopropyl)-1,4- dihydrofulleride [(Ph2)2Cr]+?[1,4- (CMe2CN)2C60]-? and bis(biphenyl)chromium(i) 1-(2-cyanoisopropyl)-1,2-
-
Gotkis,Cloke
, p. 2710 (1934)
-
Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation
Pérez, Juana M.,Postolache, Roxana,Casti?eira Reis, Marta,Sinnema, Esther G.,Vargová, Denisa,De Vries, Folkert,Otten, Edwin,Ge, Luo,Harutyunyan, Syuzanna R.
supporting information, p. 20071 - 20076 (2021/12/03)
Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.
Method for preparing (methyl) acrylonitrile by dehydration of (methyl) acrylamide
-
Paragraph 0025-0093, (2019/12/11)
The invention relates to the field of fine chemical industry, and in particular relates to a method for preparing (methyl) acrylonitrile by dehydration of (methyl) acrylamide. The method for preparingthe (methyl) acrylonitrile by dehydration of secondary catalytic raw material (methyl) acrylamide comprises the following steps: firstly, carrying out dehydration reaction on the (methyl) acrylamidein a homogeneous system, and then carrying out secondary catalytic dehydration reaction in a reaction bed by using a mesoporous organometallic palladium catalyst. The method can reduce the generationof waste water and waste, and has relatively higher (methyl) acrylamide conversion rate and higher (methyl) acrylonitrile single-pass yield. The method has mild reaction conditions, rapid reaction, simple process and easy operation, and is suitable for industrial production.