1309877-90-4Relevant articles and documents
Trisubstituted ureas as potent and selective mPGES-1 inhibitors
Chiasson, Jean-Franois,Boulet, Louise,Brideau, Christine,Chau, Anh,Claveau, David,C?té, Bernard,Ethier, Diane,Giroux, André,Guay, Jocelyne,Guiral, Sébastien,Mancini, Joseph,Massé, Frédéric,Méthot, Nathalie,Riendeau, Denis,Roy, Patrick,Rubin, Joel,Xu, Daigen,Yu, Hongping,Ducharme, Yves,Friesen, Richard W.
, p. 1488 - 1492 (2011/04/23)
A novel series of trisubstituted ureas has been identified as potent and selective mPGES-1 inhibitors. These compounds are selective over other prostanoid enzymes such as PGF synthase and TX synthase. This series of inhibitors was developed by lead optimi
