1309922-72-2

Upstream product

• 69-65-8 mannitol 
• 3969-59-3 mannitol triacetonide 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 166239-53-8 (E)-3-[(4R,5R)-5-((E)-2-Ethoxycarbonyl-vinyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-acrylic acid ethyl ester 
• 155128-49-7 Diethyl (+)-(4R,5R)-4,5-O-isopropylidene-4,5-dihydroxyoctanedioate 
• 129213-64-5 (R,R')-tetrahydro<2,2'-bifuran>-5,5'(2H,2'H)-dione 
• 1309922-62-0 C₁₄H₂₂O₆ 
• 1309922-63-1 C₁₄H₁₈O₄ 
• 1309922-64-2 (2R,2'R,4R,4'R)-4,4'-diisopropyl-tetrahydro-2,2'-bifuran-5,5'(2H,2'H)-dione 
• 1309922-65-3 (3S,5R)-5-((1R,3S)-1-Hydroxy-3-(4-methoxy-3-(methoxypropoxy)benzoyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one 
• 1309922-70-0 (3S,5R)-5-((1R,3S)-1-hydroxy-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one 
• 1309922-71-1 (1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate 
• 1607844-98-3 C₁₄H₁₈O₄ 
• 148515-21-3 ethyl 2-(diethoxyphosphoryl)-3-methylbutyrate 

Downstream Products

• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 1206809-73-5 (3S,5R)-5-((1S,3S)-1-amino-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 1607844-94-9 (2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 1607844-95-0 (3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 

Relevant academic research and scientific papers

A aliskiren or its salt separation and analysis method

The invention relates to a separation analysis method using polysaccharide derivative-bonded and coated silica as a stationary phase and an organic solvent as a mobile phase for separation analysis of aliskiren and isomers thereof, effective separation of the aliskiren and isomers thereof can be realized, and the separation analysis method has the important meaning to the product quality control.

A Total synthesis of aliskiren starting from D-Tartrate diester

A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.

A NOVEL PROCESS FOR MAKING ALISKIREN, ITS NOVEL INTERMEDIATES AND CERTAIN NOVEL COMPOUNDS

A novel process for making Renin inhibitors like Aliskiren is disclosed. Its novel intermediate compounds and method of making them are also disclosed.