1309922-65-3

Upstream product

• 148515-21-3 ethyl 2-(diethoxyphosphoryl)-3-methylbutyrate 
• 1607844-98-3 C₁₄H₁₈O₄ 
• 155128-49-7 Diethyl (+)-(4R,5R)-4,5-O-isopropylidene-4,5-dihydroxyoctanedioate 
• 166239-53-8 (E)-3-[(4R,5R)-5-((E)-2-Ethoxycarbonyl-vinyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-acrylic acid ethyl ester 
• 173336-76-0 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene 
• 1309922-64-2 (2R,2'R,4R,4'R)-4,4'-diisopropyl-tetrahydro-2,2'-bifuran-5,5'(2H,2'H)-dione 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 3969-59-3 mannitol triacetonide 
• 69-65-8 mannitol 
• 1309922-63-1 C₁₄H₁₈O₄ 
• 1309922-62-0 C₁₄H₂₂O₆ 
• 129213-64-5 (R,R')-tetrahydro<2,2'-bifuran>-5,5'(2H,2'H)-dione 

Downstream Products

• 1309922-66-4 C₂₆H₄₀O₉S 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 1309922-67-5 C₂₅H₃₇N₃O₆ 
• 1309922-68-6 C₃₀H₄₇NO₇ 
• 934841-32-4 C₃₀H₄₇NO₇ 
• 1309922-69-7 C₃₅H₅₉N₃O₈ 
• 1309922-70-0 (3S,5R)-5-((1R,3S)-1-hydroxy-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one 
• 1309922-71-1 (1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate 
• 1309922-72-2 (3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one 
• 1607844-94-9 (2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 1607844-95-0 (3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 

Relevant academic research and scientific papers

A Total synthesis of aliskiren starting from D-Tartrate diester

A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.

A NOVEL PROCESS FOR MAKING ALISKIREN, ITS NOVEL INTERMEDIATES AND CERTAIN NOVEL COMPOUNDS

A novel process for making Renin inhibitors like Aliskiren is disclosed. Its novel intermediate compounds and method of making them are also disclosed.