130993-45-2

Upstream product

• 130993-44-1 (1',2'-trans)-3-phenyl-1-<2'-(N-pyrrolidinyl)cyclohexyl>-2-pyrrolidinone 
• 130993-44-1 (1',2'-trans)-3-phenyl-1-<2'-(N-pyrrolidinyl)cyclohexyl>-2-pyrrolidinone 
• 130993-48-5 4-chloro-2-phenyl-N-<2'-(N-pyrrolidinyl)cyclohexyl>butyramide 
• 93273-13-3 4-chloro-2-phenylbutyronitrile 
• 286-20-4 cyclohexane-1,2-epoxide 
• 130993-49-6 4-iodo-2-phenylbutyronitrile 
• 130993-47-4 4-chloro-2-phenylbutanoic acid 
• 130993-50-9 7-<(3'-cyano-3'-phenyl)propyl>-7-azabicyclo<4.1.0>heptane 
• 26785-37-5 (+/-)-trans-2-(pyrrolidin-1-yl)cyclohexanamine 

Relevant academic research and scientific papers

Synthesis of (1',2'-trans)-3-phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones as κ-selective opiates

(1',2'-trans)-3-Phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones (1 and 2) and their 3,4-dichlorophenyl analogues (4 and 5) were synthesized as lactam analogues of U-50,488 (I; a κ-opiate analgesic developed by Upjohn Company). Compounds 1 and 2 w