130993-49-6

Upstream product

• 52370-86-2 ethyl 4-chloro-2-cyano-2-phenylbutanoate 
• 4553-07-5 ethyl phenylcyanoacetate 
• 93273-13-3 4-chloro-2-phenylbutyronitrile 

Downstream Products

• 130993-50-9 7-<(3'-cyano-3'-phenyl)propyl>-7-azabicyclo<4.1.0>heptane 
• 58323-63-0 4-(morpholin-4-yl)-2-phenylbutanenitrile 
• 50599-78-5 4-dimethylamino-2-phenyl-butyronitrile 
• 130993-44-1 (1',2'-trans)-3-phenyl-1-<2'-(N-pyrrolidinyl)cyclohexyl>-2-pyrrolidinone 
• 130993-44-1 (1',2'-trans)-3-phenyl-1-<2'-(N-pyrrolidinyl)cyclohexyl>-2-pyrrolidinone 
• 130993-45-2 3-hydroxy-3-phenyl-1-<2'-(N-pyrrolidinyl)cyclohexyl>-2-pyrrolidinone 

Relevant academic research and scientific papers

3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS

Compounds of formula (I), processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta ( CSNK1α and/or 6) useful for the treatment of proliferative disorders. (l)

Synthesis of (1',2'-trans)-3-phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones as κ-selective opiates

(1',2'-trans)-3-Phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones (1 and 2) and their 3,4-dichlorophenyl analogues (4 and 5) were synthesized as lactam analogues of U-50,488 (I; a κ-opiate analgesic developed by Upjohn Company). Compounds 1 and 2 w